coaX

coaX
168

type III pantothenate kinase

Locus
BSU_00700
Molecular weight
26.07 kDa
Isoelectric point
8.37
Protein length
258 aaSequenceBlast
Gene length
777 bpSequenceBlast
Function
biosynthesis of coenzyme A
Product
pantothenate kinase
Essential
no
E.C.
2.7.1.33
Synonyms
coaX, yacB
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1521 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
79,092  79,868
Phenotypes of a mutant
a coaA coaX double mutant is not viable PubMed
The protein
Catalyzed reaction/ biological activity
(R)-pantothenate + ATP --> (R)-4'-phosphopantothenate + ADP + H+ PubMed
Protein family
type III pantothenate kinase family (single member, according to UniProt)
Cofactors
requires NH4+ for activity PubMed
Structure
2H3G (PDB) (from Bacillus anthracis str. ames, 75% identity, 88% similarity) PubMed
P37564 (AlphaFold)
Localization
cytoplasm (according to UniProt)
Expression and Regulation
Operons
Genes
coaX-yacC-yacD-cysK
Description
PubMed
Regulation
induced by heat stress (Spx) PubMed
Regulatory mechanism
Spx: activation, PubMed, in spx regulon
Sigma factors
SigM: sigma factor, PubMed, in sigM regulon
Open in new tab

coaX→cysK

2025-03-17 17:57:52

Jstuelk

142

9ef1e909d5470f714eecab6c2a37a360ff5a937a

003644EA8BBEA39BF437B882590C41426A16D68B

Genes
coaX-yacC
Description
PubMed
Sigma factors
SigM: sigma factor, PubMed, in sigM regulon
Open in new tab

coaX→yacC

2025-03-20 17:15:12

ghost

98

1eddea650a1c473f508201dc69b087c661eb3247

F8A009EE624CB7514C6AD2BA5C39B3D130F9E5CF

Biological materials
Mutant
MGNA-B923 (yacB::erm), available at the NBRP B. subtilis, Japan
BKE00700 (coaX::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CAACCTCTATCACCACTTTT,  downstream forward: _UP4_GGAAGTGTATAGGAGGTTTA
BKK00700 (coaX::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CAACCTCTATCACCACTTTT,  downstream forward: _UP4_GGAAGTGTATAGGAGGTTTA
GP3356 (coaX::lox72), available in Jörg Stülke's lab
GP3381 (coaX::neo trpC2), available in Jörg Stülke's lab PubMed
References
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9B8EAD4EDDA97526D4462F6F3205F81FECD039DE

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Time of last update: 2025-04-06 06:46:22

Author of last update: Jstuelk