epr
168

minor extracellular serine protease, involved in control of swarming motility

Locus

BSU_38400

Molecular weight

69.52 kDa

Isoelectric point

9.88

Protein length

645 aaSequenceBlast

Gene length

1938 bpSequenceBlast

Function

protein degradation

Product

minor extracellular serine protease

Essential

Synonyms

epr, ipa-15r

Outlinks

BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

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Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1404 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene

Coordinates

3,939,869 → 3,941,806

The protein

Protein family

peptidase S8 family (according to UniProt)

Domains

Peptidase S8 domain (aa 115-382) (according to UniProt)

Structure

3WHI (PDB) (Subtilisin, corresponds to aa 27 ... 382, 40% identity) PubMed

P16396 (AlphaFold)

Localization

extracellular (signal peptide) PubMed

Expression and Regulation

Operons

Genes

epr

Description

PubMed

Regulation

repressed by SinR PubMed

Regulatory mechanism

SinR: repression, PubMed, in sinR regulon

ScoC: repression, PubMed, in scoC regulon

Spo0A: activation, in spo0A regulon

DegU: activation, not activated by DegU-P PubMed, in degU regulon

Sigma factors

SigD: sigma factor, PubMed, in sigD regulon

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Biological materials

Mutant

1A1021 ( epr::tet), PubMed, available at BGSC

KO7 (ΔnprE ΔaprE Δepr Δmpr ΔnprB Δvpr Δbpr), available as BGSC 1A1133

BKE38400 (Δepr::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATGATTCATCTCCTTTTTC, downstream forward: _UP4_TAACCAAAAACCTTTAAGAT

BKK38400 (Δepr::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATGATTCATCTCCTTTTTC, downstream forward: _UP4_TAACCAAAAACCTTTAAGAT

References

Reviews

Original Publications

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Time of last update: 2025-04-04 13:47:33

Author of last update: Jstuelk

epr 168

epr
168