flgM

flgM
168

anti-SigD, regulation of flagellin, Motility and chemotaxis

Locus
BSU_35430
Molecular weight
9.86 kDa
Isoelectric point
9.92
Protein length
88 aaSequenceBlast
Gene length
267 bpSequenceBlast
Function
control of SigD activity
Product
anti-SigD
Essential
no
Synonyms
flgM
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG2747 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,640,285 → 3,640,551
Phenotypes of a mutant
defective in Swarming motility PubMed
The protein
Protein family
flgM family (single member, according to UniProt)
Structure
1RP3 (PDB) (SigD-FlgM complex from Aqufex aeolicus, 34% identity) PubMed
P39809 (AlphaFold)
Localization
secreted and extracellularly degraded by the proteases Epr and WprA PubMed
secretion of FlgM requires the FliF/FliG basal body proteins, the flagellar type III export apparatus components FliO, FliP, FliQ, FliR, FlhA, and FlhB, and the substrate specificity switch regulator FliK PubMed
Expression and Regulation
Operons
Genes
comFA-comFB-comFC-yvyF-flgM-flgN-flgK-flgL-yviE-fliW-csrA
Description
PubMed
Expression
expression is heterogeneous PubMed
Regulatory mechanism
ComK: activation, PubMed, in comK regulon
DegU: activation, DegU-P, PubMed, in degU regulon
ScoC: repression, PubMed, in scoC regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
SigD: sigma factor, PubMed, in sigD regulon
Open in new tab

comFA→csrA

2025-03-28 01:21:10

Jstuelk

156

F13A7084BCCB15345BC26C03AF15EE753EFDF196

11180672E46D33F7D747E58441ECB10AEE7F8D8B

Genes
flgM-flgN-flgK-flgL
Description
PubMed
Open in new tab

flgM→flgL

2025-03-17 17:09:29

ghost

100

ea02f383b0b547b9936fb15477617f2d69313a11

85B60E6460B7DC58F7D89F65555D10DC02C9174C

Genes
yvyF-flgM-flgN-flgK-flgL
Description
PubMed
Open in new tab

yvyF→flgL

2025-04-04 13:12:46

ghost

146

54b504e5188fb5cc1a6644d55c8b17ab69ba9d56

BC4D7E6A3A36ACBE2957E285D8B37ED05A361235

Biological materials
Mutant
1A764 (no resistance), PubMed, available at BGSC
BKE35430 (ΔflgM::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATAGGATTCCTCTCGCTTT,  downstream forward: _UP4_AAGCAATAAAAAAGGAGAAA
BKK35430 (ΔflgM::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATAGGATTCCTCTCGCTTT,  downstream forward: _UP4_AAGCAATAAAAAAGGAGAAA
References
Reviews
Loading
Original Publications
Loading

F03144BF8A187C8931938A21433431B8961E8EE7

Page visits: 6103

Time of last update: 2025-04-04 08:08:59

Author of last update: Jstuelk