fliG

fliG
168

flagellar basal-body protein, membrane anchor of the basal body, flagellar motor switch protein, physically transduces force from MotA to the rotation of FliF

Locus
BSU_16220
Molecular weight
38.04 kDa
Isoelectric point
4.46
Protein length
338 aaSequenceBlast
Gene length
1017 bpSequenceBlast
Function
movement and chemotaxis
Product
flagellar C ring protein
Essential
no
Synonyms
fliG, flaA15
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1536 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
1,694,119  1,695,135
Phenotypes of a mutant
mucoid phenotype due to the overproduction of poly-gamma-glutamate PubMed
no secretion of FlgM, permanent inhibition of SigD PubMed
defective in Swarming motility PubMed
The protein
Catalyzed reaction/ biological activity
physically transduces force from MotA to the rotation of FliF
Protein family
FliG family (single member, according to UniProt)
Structure
3HJL (PDB) (from Aquifex aeolicus, 31% identity) PubMed
P23448 (AlphaFold)
Effectors of protein activity
interaction with EpsE prevents energetization of the flagellum by MotA-MotB PubMed
Localization
cell membrane (according to UniProt)
Expression and Regulation
Operons
Genes
flgB-flgC-fliE-fliF-fliG-fliH-fliI-fliJ-ylxF-fliK-flgD-flgE-swrD-fliL-fliM-fliY-cheY-fliO-fliP-fliQ-fliR-flhB-flhA-flhF-flhG-cheB-cheA-cheW-cheC-cheD-sigD-swrB
Description
PubMed
Regulation
expression during spore germination is strongly reduced under conditions of osmotic stress PubMed
Regulatory mechanism
Spo0A: repression, in spo0A regulon
SwrA: activation, in swrA regulon
CodY: repression, in codY regulon
DegU: repression, in degU regulon
SinR: transcription elongation, binding of the SinR-SlrR heteromer to sites within fliE and fliI results in inhibition of transcription elongation PubMed, in sinR regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
SigD: sigma factor, PubMed, in sigD regulon
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flgB→swrB

2025-04-03 01:56:48

Jstuelk

173

024d59ae468aa14568753f57122b789c39ed6c06

4D920B925DA071AE7390E022B9AB625E40B7B2AC

Biological materials
Mutant
BKE16220 (fliG::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_ACGTCTCGCCATTTCTAATT,  downstream forward: _UP4_TAATATCATTAAACAAGAAT
BKK16220 (fliG::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_ACGTCTCGCCATTTCTAATT,  downstream forward: _UP4_TAATATCATTAAACAAGAAT
References
Reviews
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Original Publications
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8DDCC3D139ACCB635BF014946E1282A72D535390

Page visits: 5523

Time of last update: 2025-04-06 22:18:47

Author of last update: Jstuelk