fliL

fliL
168

flagellar protein required for flagellar formation, membrane protein, associates with and regulate ion flow through the stator complex

Locus
BSU_16300
Molecular weight
15.45 kDa
Isoelectric point
5.18
Protein length
140 aaSequenceBlast
Gene length
423 bpSequenceBlast
Function
movement and chemotaxis
Product
flagellar protein required for flagellar formation, membrane protein
Essential
no
Synonyms
fliL
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1580 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
1,701,228  1,701,650
Phenotypes of a mutant
defective in Swarming motility PubMed
The protein
Protein family
FliL family (single member, according to UniProt)
Structure
P23452 (AlphaFold)
Localization
cell membrane (according to UniProt)
Expression and Regulation
Operons
Genes
ylxF-fliK-flgD-flgE-swrD-fliL-fliM-fliY-cheY-fliO-fliP-fliQ-fliR-flhB-flhA-flhF-flhG-cheB-cheA-cheW-cheC-cheD-sigD-swrB
Description
PubMed
Regulation
see fla-che operon
Regulatory mechanism
Spo0A: repression, in spo0A regulon
CodY: repression, in codY regulon
DegU: repression, in degU regulon
SwrA: activation, in swrA regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
SigD: sigma factor, PubMed, in sigD regulon
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ylxF→swrB

2025-04-04 21:21:07

Jstuelk

170

EECFE9022742ECC57D9BBA5CE7DB7A4D1BFD42A8

0535E3D13CBD000A94D62050515BF8D1D5E3F011

Genes
flgB-flgC-fliE-fliF-fliG-fliH-fliI-fliJ-ylxF-fliK-flgD-flgE-swrD-fliL-fliM-fliY-cheY-fliO-fliP-fliQ-fliR-flhB-flhA-flhF-flhG-cheB-cheA-cheW-cheC-cheD-sigD-swrB
Description
PubMed
Regulation
expression during spore germination is strongly reduced under conditions of osmotic stress PubMed
Regulatory mechanism
Spo0A: repression, in spo0A regulon
SwrA: activation, in swrA regulon
CodY: repression, in codY regulon
DegU: repression, in degU regulon
SinR: transcription elongation, binding of the SinR-SlrR heteromer to sites within fliE and fliI results in inhibition of transcription elongation PubMed, in sinR regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
SigD: sigma factor, PubMed, in sigD regulon
Open in new tab

flgB→swrB

2025-04-03 01:56:48

Jstuelk

173

024d59ae468aa14568753f57122b789c39ed6c06

4D920B925DA071AE7390E022B9AB625E40B7B2AC

Biological materials
Mutant
BKE16300 (fliL::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CTTCATTCCGGTTCCTCTAT,  downstream forward: _UP4_TAAAGCATAATTTGACAGAA
BKK16300 (fliL::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CTTCATTCCGGTTCCTCTAT,  downstream forward: _UP4_TAAAGCATAATTTGACAGAA
References
Reviews
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Original Publications
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2CCB8AD9238D18BA2361020A671844C021E81EE0

Page visits: 5616

Time of last update: 2025-04-07 03:27:37

Author of last update: Jstuelk