lysC
168
aspartokinase II (alpha and beta subunits)
Locus
BSU_28470
Molecular weight
43.65 kDa
Isoelectric point
4.64
Function
biosynthesis of lysine
Product
aspartokinase II (alpha and beta subunits)
Essential
no
E.C.
2.7.2.4
Synonyms
lysC, ask, aecA
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0527 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
2,909,520 2,910,746
The protein
Catalyzed reaction/ biological activity
ATP + L-aspartate --> 4-phospho-L-aspartate + ADP (according to UniProt)
Protein family
two C-terminal ACT domains (aa 264-337, and aa 343-408) (according to UniProt)
Structure
2RE1 (PDB) (from Neisseria meningitidis mc58, 40% identity, 58% similarity)
Effectors of protein activity
feedback inhibition by lysine PubMed
Paralogous protein(s)
cytoplasm (according to UniProt)
Additional information
subject to Clp-dependent proteolysis upon glucose starvation PubMed, also degraded upon ammonium or amino acid starvation PubMed
belongs to the 100 most abundant proteins PubMed
Expression and Regulation
Operons
Genes
Description
Regulation
expression activated by glucose (5.4 fold) PubMed
Regulatory mechanism
L-box: RNA switch, via a riboswitch, in L-box
Biological materials
Mutant
References
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Time of last update: 2025-04-05 11:40:10
Author of last update: Jstuelk