melR

melR
168

transcriptional regulator of the melR-melE-melD-melC-melA operon

Locus
BSU_30260
Molecular weight
38.24 kDa
Isoelectric point
6.45
Protein length
344 aaSequenceBlast
Gene length
1035 bpSequenceBlast
Function
regulation of melibiose utilization
Product
transcriptional regulator (LacI family)
Essential
no
Synonyms
melR, msmR
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1609 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,096,782  3,097,816
The protein
Catalyzed reaction/ biological activity
represses the the melR-melE-melD-melC-melA operon in the absence of melibiose or raffinose PubMed
Protein family
LacI family
Domains
HTH lacI-type domain (aa 2-58) (according to UniProt)
Structure
1VPW (PDB) (E. coli PurR, 29% identity) PubMed
O34829 (AlphaFold)
Expression and Regulation
Operons
Genes
melR-melE-melD-melC-melA
Description
PubMed
Regulation
repressed by glucose (CcpA) PubMed
Regulatory mechanism
CcpA: repression, PubMed, in ccpA regulon
MelR: repression, PubMed, in melR regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
Open in new tab

melR→melA

2025-04-02 19:59:37

ghost

91

a76a3bd8bbf487172d83c078a68b2450f4f95213

AB0F662445BB81BBCFC1971F2E98536D4BBE6D03

Biological materials
Mutant
MGNA-A802 (msmR::erm), available at the NBRP B. subtilis, Japan
BKE30260 (melR::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATGGGTATCCCTCTCATCT,  downstream forward: _UP4_TAAGCAAAGATTCATCACGA
BKK30260 (melR::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATGGGTATCCCTCTCATCT,  downstream forward: _UP4_TAAGCAAAGATTCATCACGA
References
Loading

58276E6FEF9388BBC7FB79BB5A3A1EF3C3DA5BD5

Page visits: 5127

Time of last update: 2025-04-05 20:21:06

Author of last update: Melvin.boenninger