murD

murD
168

UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase

Locus
BSU_15200
Molecular weight
49.49 kDa
Isoelectric point
5.57
Protein length
451 aaSequenceBlast
Gene length
1356 bpSequenceBlast
Function
peptidoglycan precursor biosynthesis
Product
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase
Essential
yes
E.C.
6.3.2.9
Synonyms
murD
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0771 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
1,588,901  1,590,256
Phenotypes of a mutant
essential PubMed
The protein
Catalyzed reaction/ biological activity
ATP + D-glutamate + UDP-N-acetyl-α-D-muramoyl-L-alanine --> ADP + H+ + phosphate + UDP-N-acetyl-α-D-muramoyl-L-alanyl-D-glutamate (according to UniProt)
Protein family
MurCDEF family (according to UniProt)
Structure
3LK7 (PDB) (from Streptococcus agalactiae, 50% identity)
Q03522 (AlphaFold)
Localization
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
Genes
murE-mraY-murD-spoVE-murG-murB-divIB-ylxW-ylxX-sbp
Description
PubMed
Regulation
expressed during vegatative growth PubMed
Regulatory mechanism
stringent response: negative regulation, in stringent response
SpoIIID: repression, PubMed, in spoIIID regulon
Sigma factors
SigE: sigma factor, PubMed, in sigE regulon
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murE→sbp

2025-04-07 16:30:23

Jstuelk

118

68c6899b3f1263bd636c35a4ea9512c00078a714

2F040145AC628A38E3D11955965F4DA256DE6790

References
Reviews
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Original Publications
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Page visits: 4620

Time of last update: 2025-04-07 08:25:13

Author of last update: Jstuelk