pbpH
168
class B penicillin-binding protein H, required for cell wall synthesis during cell elongation, works together with RodA in the elongasome for lateral cell wall synthesis and control of cell diameter
Locus
BSU_13980
Molecular weight
76.98 kDa
Isoelectric point
8.89
Function
formation of a rod-shaped peptidoglycan cell wall
Product
penicillin-binding protein H
Essential
no
Synonyms
pbpH, ykuA
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0768 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
The protein
Catalyzed reaction/ biological activity
required for cell wall synthesis during cell elongation PubMed
Protein family
transpeptidase family (according to UniProt)
Structure
2WAF (PDB) (Pbp2B from Streptococcus pneumoniae, 31% identity) PubMed
Paralogous protein(s)
during vegetative growth: evenly distributed along the membrane PubMed
localization depends on the availability of peptidoglyan precursors (lipid II) PubMed
Additional information
loss of activity at alkaline pH8.5 PubMed
Expression and Regulation
Operons
Biological materials
Mutant
MGNA-B335 (ykuA::erm), available at the NBRP B. subtilis, Japan
GFP fusion
References
Reviews
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Original Publications
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Time of last update: 2025-04-07 02:08:21
Author of last update: Jstuelk