pyrR

pyrR
168

transcriptional termination factor of the pyr operon

Locus
BSU_15470
Molecular weight
20.12 kDa
Isoelectric point
4.99
Protein length
181 aaSequenceBlast
Gene length
546 bpSequenceBlast
Function
regulation of pyrimidine biosynthesis
Product
transcriptional termination protein with minor uracil phosphoribosyltransferase activity
Essential
no
E.C.
2.4.2.9
Synonyms
pyrR
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG2065 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
1,618,304  1,618,849
The protein
Catalyzed reaction/ biological activity
diphosphate + UMP --> 5-phospho-α-D-ribose 1-diphosphate + uracil (according to UniProt)
Protein family
Purine/pyrimidine phosphoribosyltransferase family (according to UniProt)
Structure
1A3C (PDB) (dimeric form)
P39765 (AlphaFold)
Effectors of protein activity
UMP and UTP stimulate the RNA-binding activity of PyrR, resulting of transcription termination of the pyrR-pyrP-pyrB-pyrC-pyrAA-pyrAB-pyrK-pyrD-pyrF-pyrE operon PubMed
Expression and Regulation
Operons
Genes
pyrR-pyrP-pyrB-pyrC-pyrAA-pyrAB-pyrK-pyrD-pyrF-pyrE
Description
PubMed
Regulation
induced in the absence of uridine nucleotides (PyrR) PubMed
Regulatory mechanism
PyrR: termination, via RNA switch, in pyrR regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
Open in new tab

pyrR→pyrE

2025-03-26 16:59:11

ghost

111

3b978222b0b6a5230a2e7701ac35d1e35cc85307

0A8FD5CB6489EDD8CB2074130B763DCAC1F24654

Genes
pyrR
Description
PubMed
Open in new tab

pyrR

2025-03-16 18:47:07

Jstuelk

58

305c42415b64122f6470a1378562465d671b32a9

C4B357F72FB9F3205FCEF82A9CAF6DEBE1BFCA8C

Genes
lspA-rluD-pyrR
Description
PubMed
Open in new tab

lspA→pyrR

2025-04-03 09:35:40

Jstuelk

82

8de7ab701af29d04cf1775c3714df5244d59efd2

D260A981278938463A8A0903EAC8DF3268BD4008

Biological materials
Mutant
BKE15470 (pyrR::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CAATGTGTGACACCTCACAG,  downstream forward: _UP4_GCCATTTATGAAAACGAATA
BKK15470 (pyrR::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CAATGTGTGACACCTCACAG,  downstream forward: _UP4_GCCATTTATGAAAACGAATA
References
Reviews
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Original Publications
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6D9CEDC7737CCFA838EBC142CD735E066C950AD2

Page visits: 5019

Time of last update: 2025-04-06 05:03:15

Author of last update: Jstuelk