sfp/1

sfp/1
168

4-phosphopantetheinyl transferase (surfactin synthetase-activating enzyme), required for production of surfactin, plipastatin and bacillaene, inactive pseudogene in strain 168

Locus
BSU_03569
Protein length
55 aaSequenceBlast
Gene length
168 bpSequenceBlast
Function
phosphopantetheinylates a serine residue in each of the seven peptidyl carrier protein domains of the first three subunits of surfactin synthetase (SrfAA-SrfAB-SrfAC) and AcpK
Product
4-phosphopantetheinyl transferase
Essential
no
E.C.
null
Synonyms
sfp/1, sfp
Outlinks
BsubCyc SubtiList Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

This gene is a member of the following regulons

Gene
Coordinates
407,460  407,627
Phenotypes of a mutant
No swarming motility on B medium. PubMed
The protein
Catalyzed reaction/ biological activity
CoA + apo-[peptidyl-carrier protein] = adenosine 3',5'-bisphosphate + holo-[peptidyl-carrier protein] (according to Swiss-Prot)
Protein family
Gsp/sfp/hetI/acpT family (according to Swiss-Prot)
Biological materials
Mutant
BKE03569 (sfp/1::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CTGGTGCAGGCGCACTGAAA,  downstream forward: _UP4_ACAATGGTCTCGTACGAAGA
BKK03569 (sfp/1::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CTGGTGCAGGCGCACTGAAA,  downstream forward: _UP4_ACAATGGTCTCGTACGAAGA
Labs working on this gene/protein
Mohamed Marahiel, Marburg University, Germany homepage
References
Reviews
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Original Publications
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1C4F076D54F5A07AC351D722A403F249ED097555

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Time of last update: 2025-04-03 16:07:03

Author of last update: Jstuelk