yacD

yacD
168

putative peptidyl-prolyl cis-trans isomerase, similar to secretion protein PrsA

Locus
BSU_00720
Molecular weight
33.94 kDa
Isoelectric point
4.95
Protein length
297 aaSequenceBlast
Gene length
894 bpSequenceBlast
Function
unknown
Product
unknown
Essential
no
Synonyms
yacD
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0760 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
80,802  81,695
The protein
Catalyzed reaction/ biological activity
[protein]-peptidylproline (ω=180) --> [protein]-peptidylproline (ω=0) (according to UniProt)
peptidyl-prolyl cis-trans isomerase activity (according to UniProt)
Domains
PpiC domain (aa 154-247) (according to UniProt)
Structure
5EZ1 (PDB) (from Helicobacter pylori, 26% identity) PubMed
P37566 (AlphaFold)
Localization
extracellular (with signal peptide) (according to UniProt)
Expression and Regulation
Operons
Genes
coaX-yacC-yacD-cysK
Description
PubMed
Regulation
induced by heat stress (Spx) PubMed
Regulatory mechanism
Spx: activation, PubMed, in spx regulon
Sigma factors
SigM: sigma factor, PubMed, in sigM regulon
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coaX→cysK

2025-03-17 17:57:52

Jstuelk

142

9ef1e909d5470f714eecab6c2a37a360ff5a937a

003644EA8BBEA39BF437B882590C41426A16D68B

Biological materials
Mutant
MGNA-B925 (yacD::erm), available at the NBRP B. subtilis, Japan
BKE00720 (yacD::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CAAACCTGCTTTCAGCCCCT,  downstream forward: _UP4_TGATTGACAAAAAATTTTGA
BKK00720 (yacD::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CAAACCTGCTTTCAGCCCCT,  downstream forward: _UP4_TGATTGACAAAAAATTTTGA
References
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Page visits: 2256

Time of last update: 2025-04-02 18:03:30

Author of last update: Jstuelk