bmrD

bmrD
168

multidrug ABC transporter (ATP-binding protein), also involved in the signalling pathway to activate KinA at the onset of sporulation

Locus
BSU_09720
Molecular weight
76.12 kDa
Isoelectric point
7.08
Protein length
673 aaSequenceBlast
Gene length
2022 bpSequenceBlast
Function
multiple antibiotic resistance
Product
multidrug ABC transporter (ATP-binding protein)
Essential
no
Synonyms
bmrD, yheH
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1132 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
1,047,072  1,049,093
The protein
Protein family
ABC transporter superfamily (according to UniProt)
Domains
has both a membrane-spanning and an ATP-binding domain PubMed
ABC transmembrane type-1 domain (aa 18-398) (according to UniProt)
ABC transporter domain (aa 430-664) (according to UniProt)
Structure
7M33 (PDB) PubMed
5MKK (PDB) (TmrAB complex from Thermus thermophilus, 38% identity) PubMed
O07549 (AlphaFold)
Paralogous protein(s)
YgaD
Localization
cell membrane PubMed
Expression and Regulation
Operons
Genes
bmrB-bmrX-bmrC-bmrD
Description
PubMed
Regulation
bmrB-bmrX-bmrC-bmrD expression only occurs during the late-exponential and stationary growth stages (AbrB) PubMed
RNA processing in the intergenic region between bmrB and bmrC (in bmrX) (Rae1) PubMed
Expression
expression is increased upon depletion of depletion of tRNA maturation factors rnpB or rnz PubMed
Regulatory mechanism
AbrB: repression, PubMed, in abrB regulon
BmrB: attenuation, PubMed, in bmrB regulon
Open in new tab

bmrB→bmrD

2025-04-07 05:44:24

Jstuelk

142

5133AE29C8DE1B1184B38190144E212977A8B571

6093E35E651F3CE8574990742E33F0A5554BD884

Biological materials
Mutant
MGNA-B491 (yheH::erm), available at the NBRP B. subtilis, Japan
BKE09720 (bmrD::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_TCTCCATAACGTTTTTCCTA,  downstream forward: _UP4_TAACGCTCAAAAACCCAAAA
BKK09720 (bmrD::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_TCTCCATAACGTTTTTCCTA,  downstream forward: _UP4_TAACGCTCAAAAACCCAAAA
References
Reviews
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Original Publications
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9B2766D2F8892AA17DB480216570C81C33355C3B

Page visits: 5342

Time of last update: 2025-04-07 14:46:58

Author of last update: Jstuelk