znuA

znuA
168

high-affinity ABC transporter for zinc (binding protein, lipoprotein)

Locus
BSU_02850
Molecular weight
35.51 kDa
Isoelectric point
5.15
Protein length
319 aaSequenceBlast
Gene length
960 bpSequenceBlast
Function
zinc uptake
Product
ABC transporter for zinc (binding protein)
Essential
no
Synonyms
znuA, ycdH
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

List of homologs in different organisms, belongs to COG0803 (Galperin et al., 2021)

This gene is a member of the following regulons

SigA regulon, Zur regulon

Gene
Coordinates
308,332 → 309,291
Phenotypes of a mutant
reduced genetic competence, can be rescued by the addition of excess zinc PubMed
reduced expression of the ''comFA-comFB-comFC-yvyF-flgM-flgN-flgK-flgL'' operon  PubMed
The protein
Protein family
bacterial solute-binding protein 9 family (with MntA, according to UniProt)
Structure
2O1E (PDB)
O34966 (AlphaFold)
Paralogous protein(s)
MntA
Localization
inner spore membrane PubMed
Expression and Regulation
Operons
Genes
znuA-znuC-znuB
Description
PubMed
Regulation
induced by zinc starvation (Zur) PubMed
Regulatory mechanism
Zur: repression, in the presence of zinc PubMed, in zur regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
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znuA→znuB

2025-03-16 17:47:22

ghost

121

d84622c86cda894bc37d4650ce0ef2c146681ec6

DA65C8A158A0243655AECDC10E982F7866F2A4D9

Biological materials
Mutant
BKE02850 (ΔznuA::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATATCGTATATCCCCTCTT,  downstream forward: _UP4_TAAGATAGTGTGCGCCGGAG
BKK02850 (ΔznuA::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATATCGTATATCCCCTCTT,  downstream forward: _UP4_TAAGATAGTGTGCGCCGGAG
References
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D33A144568CAF32FFE4A2A46BE67573DB66FC1A1

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Time of last update: 2025-03-16 21:12:49

Author of last update: Jstuelk