safA

safA
168

morphogenetic protein associated with SpoVID, major organizer of the inner spore coat

Locus
BSU_27840
Molecular weight
43.07 kDa
Isoelectric point
5.75
Protein length
387 aaSequenceBlast
Gene length
1164 bpSequenceBlast
Function
spore coat formation
Product
morphogenetic protein
Essential
no
Synonyms
safA, yrbA
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

List of homologs in different organisms, belongs to COG1388 (Galperin et al., 2021)

This gene is a member of the following regulons

SigE regulon

Gene
Coordinates
2,844,675 → 2,845,838
Phenotypes of a mutant
mis-assembly of the inner spore coat PubMed
The protein
Domains
contains a N-acetylglucosamine-polymer-binding LysM domain at the N-terminus PubMed
LysM domain (aa 2-47) (according to UniProt)
Structure
O32062 (AlphaFold)
Localization
inner spore coat  PubMed
cortex-coat interface PubMed
Expression and Regulation
Operons
Genes
safA-coxA
Description
PubMed
Regulation
expressed early during sporulation in the mother cell (SigE) PubMed
Sigma factors
SigE: sigma factor, PubMed, in sigE regulon
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safA→coxA

2025-03-14 18:42:11

ghost

103

12887e4fab6c1ec58f9a68216a6d2a5a398694c5

D9BDB8B92E2AC509F33C2AB81BA9EFCF29FD7237

Biological materials
Mutant
MGNA-A011 (yrbA::erm), available at the NBRP B. subtilis, Japan
1S126 ( safA::erm), PubMed, available at BGSC
1S117 ( safA::spec), PubMed, available at BGSC
BKE27840 (ΔsafA::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CAACGTTTTCCCCTCCTATG,  downstream forward: _UP4_TGATCGTTCGGAACGATGTA
BKK27840 (ΔsafA::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CAACGTTTTCCCCTCCTATG,  downstream forward: _UP4_TGATCGTTCGGAACGATGTA
Labs working on this gene/protein
Adriano Henriques, Lisbon, Portugal homepage
Charles Moran, Emory University, NC, USA homepage
References
Reviews
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Original Publications
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CEBEC9CECCF445C40D793E61A2CD23175631A473

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Time of last update: 2025-03-15 14:50:56

Author of last update: Jstuelk