lipC

lipC
168

spore coat protein, phospholipase implicated in spore germination

Locus
BSU_04110
Molecular weight
23.46 kDa
Isoelectric point
5.84
Protein length
213 aaSequenceBlast
Gene length
642 bpSequenceBlast
Function
spore germination
Product
spore coat phospholipase B
Essential
no
Synonyms
lipC, ycsK
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG2755 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
462,431  463,072
Phenotypes of a mutant
defective in L-alanine-stimulated germination PubMed
The protein
Catalyzed reaction/ biological activity
cleaves the fatty acids at the sn-1 and sn-2 positions of phospholipids PubMed
Protein family
'GDSL' lipolytic enzyme family (according to UniProt)
Structure
4PPY (PDB) (from Bacteroides fragilis, corresponds to aa 41 ... 210, 25.4% identity)
P42969 (AlphaFold)
Localization
spore coat (basement), localization depends on SpoIVA PubMed
Expression and Regulation
Operons
Genes
lipC
Description
(according to DBTBS) null
Regulation
expressed four hours after onset of sporulation (GerE) PubMed
Regulatory mechanism
GerE: activation, PubMed, in gerE regulon
Sigma factors
SigK: sigma factor, PubMed, in sigK regulon
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lipC

2025-03-15 04:58:42

Jstuelk

59

85f41d2e5f0ac35fd960f61b483f107564af1cfa

0B6EBB4D565DC56F1668FB2F86A2A93226F88EEA

Genes
pxpA-ycsG-ycsI-pxpB-pxpC-kipR-lipC
Description
PubMed
Regulation
induced in the presence of 5-oxoproline PubMed
Regulatory mechanism
KipR: repression, PubMed, in kipR regulon
TnrA: activation, PubMed, in tnrA regulon
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pxpA→lipC

2025-03-15 03:47:13

Jstuelk

101

2e345e8dee0849e85fe094a123ef62dc61c60b82

B227AB4ADF5839F5D85D0A01462013A7CDA6A81D

Biological materials
Mutant
MGNA-C024 (ycsK::erm), available at the NBRP B. subtilis, Japan
BKE04110 (lipC::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATGTTCTTTCCTCCACTCT,  downstream forward: _UP4_TAGAAAACGCGCCTCATGAC
BKK04110 (lipC::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATGTTCTTTCCTCCACTCT,  downstream forward: _UP4_TAGAAAACGCGCCTCATGAC
References
Reviews
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Original Publications
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05910B4500420D4DB75DAD3A7A2358C360FF2154

Page visits: 3850

Time of last update: 2025-03-15 20:13:56

Author of last update: Jstuelk