glpQ

glpQ
168

glycerolphosphate diester phosphodiesterase, degrades wall teichoic acid during phosphate starvation

Locus
BSU_02130
Molecular weight
32.81 kDa
Isoelectric point
9.26
Protein length
293 aaSequenceBlast
Gene length
882 bpSequenceBlast
Function
glycerol-3-phosphate utilization, degradation of wall teichoic acid during phosphate starvation
Product
glycerolphosphate diester phosphodiesterase
Essential
no
E.C.
3.1.4.46
Synonyms
glpQ, ybeD
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0584 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
233,014 → 233,895
The protein
Catalyzed reaction/ biological activity
exohydrolytic activity on wall teichoic acid, acts in concert with PhoD PubMed
removes glycerolphosphates from the free end of the unsubstituted wall teichoic acid up to the peptidoglycan linker PubMed
sn-glycero-3-phosphoester + H2O --> alcohol + H+ + sn-glycerol 3-phosphate (according to UniProt)
Protein family
glycerophosphoryl diester phosphodiesterase family (with YhdW, according to UniProt)
Domains
GP-PDE domain (aa 38-290) (according to UniProt)
Structure
5T9B (PDB) PubMed
P37965 (AlphaFold)
Paralogous protein(s)
YhdW, YqiK
Localization
extracellular (signal peptide) PubMed
Expression and Regulation
Operons
Genes
glpT-glpQ
Description
PubMed
Regulation
induced by glycerol (GlpP) PubMed
Regulatory mechanism
GlpP: antitermination, via a protein-dependent RNA switch PubMed, in glpP regulon
PhoP: activation, PubMed, in phoP regulon
CcpA: repression, in ccpA regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
Open in new tab

glpT→glpQ

2025-03-12 11:38:41

ghost

76

e21fcae2eb545caac4a51ee013af601bc96688aa

3E9AB6EA1D92E82B84D67092560AC5EC28AD9E48

Genes
glpQ
Regulation
induced by glycerol (GlpP) PubMed
Open in new tab

glpQ

2025-03-10 23:42:50

ghost

78

f9519a8adc13cc4efc98d0b5009f78016069c36e

D97DEF600BA4CCBF43E0FE575AF9B2A0A8935AA5

Biological materials
Mutant
BKE02130 (ΔglpQ::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATGATTTCTCCTCCTTATA,  downstream forward: _UP4_TAAAAGCAAAAAACCTTGCG
BKK02130 (ΔglpQ::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATGATTTCTCCTCCTTATA,  downstream forward: _UP4_TAAAAGCAAAAAACCTTGCG
References
Reviews
Loading
Original Publications
Loading

E9BEF368F8E55888AD4849E8906E517831A882DF

Page visits: 4479

Time of last update: 2025-03-15 19:50:30

Author of last update: Jstuelk