yflG

yflG
168

methionine aminopeptidase

Locus
BSU_07690
Molecular weight
27.06 kDa
Isoelectric point
5.58
Protein length
249 aaSequenceBlast
Gene length
750 bpSequenceBlast
Function
removal of N-terminal methionine from nascent proteins
Product
methionine aminopeptidase
Essential
no
Synonyms
yflG, mapB
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0024 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
839,735 → 840,484
The protein
Catalyzed reaction/ biological activity
Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides (according to UniProt)
Protein family
peptidase M24A family (with Map, according to UniProt)
Structure
1QXW (PDB) (from Staphylococcus aureus, 51% identity) PubMed
O34484 (AlphaFold)
Paralogous protein(s)
Map
Localization
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
Genes
yflG-yflH-yflI
Description
PubMed
Regulation
induced by stress (SigB) PubMed
Regulatory mechanism
NagR: repression, (weak and not certain) PubMed, in nagR regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
SigB: sigma factor, PubMed, in sigB regulon
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yflG→yflI

2025-03-02 00:33:10

Jstuelk

82

c1614d2c9c5978531b016f43a531f140bbd19647

EE6EE6B0D0F1E44D02EEBF60829D3001D9844453

Biological materials
Mutant
MGNA-C255 (yflG::erm), available at the NBRP B. subtilis, Japan
BKE07690 (ΔyflG::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATCTGTCATTCCCGCTTTC,  downstream forward: _UP4_TAAAACACATTCCGGGCTTC
BKK07690 (ΔyflG::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATCTGTCATTCCCGCTTTC,  downstream forward: _UP4_TAAAACACATTCCGGGCTTC
References
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F2DE9BFE16D7B0DAE92DB58F9B1EDFBB7557ED16

Page visits: 2608

Time of last update: 2025-03-15 09:01:02

Author of last update: Melvin.boenninger