pksD
168

involved in polyketide synthesis, similar to loading acyltransferase

Locus

BSU_17110

Molecular weight

33.91 kDa

Isoelectric point

5.78

Protein length

324 aaSequenceBlast

Gene length

975 bpSequenceBlast

Function

polyketide synthesis

Product

unknown

Essential

Synonyms

pksD

Outlinks

BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

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Categories containing this gene/protein

List of homologs in different organisms, belongs to COG3321 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene

Coordinates

1,785,133 → 1,786,107

The protein

Structure

4RL1 (PDB) (from Streptomyces avermitilis, 26% identity) PubMed

O34877 (AlphaFold)

Expression and Regulation

Operons

Genes

pksC-pksD-pksE-acpK-pksF-pksG-pksH-pksI-pksJ-pksL-pksM-pksN-pksR

Description

PubMed

Regulation

expressed during the transition from growth to stationary phase (AbrB, CodY) PubMed

heterogeneous expression, percentage of expressing cells increases during colonization of plant roots PubMed

Regulatory mechanism

AbrB: repression, PubMed, in abrB regulon

CodY: activation, PubMed, in codY regulon

Additional information

this is a very large operon comprising about 75 kb

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Genes

pksB-pksC-pksD-pksE-acpK-pksF-pksG-pksH-pksI-pksJ-pksL-pksM-pksN-pksR

Description

PubMed

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Biological materials

Mutant

BKE17110 (ΔpksD::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATGTGTATAACCTTCTTTT, downstream forward: _UP4_ACACCAGAAAGGAAGTTTAC

BKK17110 (ΔpksD::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATGTGTATAACCTTCTTTT, downstream forward: _UP4_ACACCAGAAAGGAAGTTTAC

References

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Time of last update: 2025-03-16 11:19:40

Author of last update: Jstuelk

pksD 168

pksD
168