hmp

hmp
168

flavohemoglobin, involved in resistance to nitric oxide (NO), essential for long-term survival under anaerobic conditions

Locus
BSU_13040
Molecular weight
44.57 kDa
Isoelectric point
5.7
Protein length
399 aaSequenceBlast
Gene length
1200 bpSequenceBlast
Function
resistance to NO
Product
flavohemoglobin
Essential
no
Synonyms
hmp, ykiA
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1018 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
1,372,792 → 1,373,991
The protein
Catalyzed reaction/ biological activity
NADPH + 2 nitric oxide + 2 O2 --> H+ + NADP+ + 2 nitrate (according to UniProt)
NADH + 2 nitric oxide + 2 O2 --> H+ + NAD+ + 2 nitrate (according to UniProt)
Protein family
globin family (single member, according to UniProt)
C-terminal part: flavoprotein pyridine nucleotide cytochrome reductase family (single member, according to UniProt)
Domains
FAD-binding FR-type domain (aa 152-255) (according to UniProt)
Cofactors
FAD (according to UniProt)
Structure
1CQX (PDB) (from Ralstonia eutropha, 47% identity) PubMed
P49852 (AlphaFold)
Expression and Regulation
Operons
Genes
hmp
Description
PubMed
Regulation
expressed under anaerobic conditions (ResD) PubMed
Regulatory mechanism
ResD: activation, PubMed, in resD regulon
NsrR: repression, PubMed, in nsrR regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
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hmp

2025-03-16 07:44:47

ghost

78

a907063913b16a6f3a25ecf55925190ea8ecdd77

7D290A6AA010BCB5BB06741B0FB78394F7E04455

Genes
hmp-ykjA
Description
PubMed
Regulation
expressed under anaerobic conditions (ResD) PubMed
Open in new tab

hmp→ykjA

2025-03-06 04:21:03

ghost

84

d5b693bfec4ab27d915c1a7324e8d31fb7977ba3

F88DAE66287366900528C6AFF1C8C3DF02CFC000

Biological materials
Mutant
BKE13040 (Δhmp::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATTTTATAAACAATCCTTT,  downstream forward: _UP4_TGAACACATACATGAAACTC
BKK13040 (Δhmp::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATTTTATAAACAATCCTTT,  downstream forward: _UP4_TGAACACATACATGAAACTC
References
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E272A68088B689873CE3269CFDD2DD830F3AB3E4

Page visits: 3654

Time of last update: 2025-03-14 05:27:15

Author of last update: Melvin.boenninger