sunT

sunT
168

Sublancin 168 lantibiotic ABC transporter

Locus
BSU_21470
Molecular weight
81.38 kDa
Isoelectric point
8.39
Protein length
705 aaSequenceBlast
Gene length
2118 bpSequenceBlast
Function
Sublancin export and processing
Product
Sublancin 168 lantibiotic ABC transporter
Essential
no
Synonyms
sunT, yolH
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

List of homologs in different organisms, belongs to COG2274 (Galperin et al., 2021)

This gene is a member of the following regulons

AbrB regulon, YvrHb regulon, Rok regulon, DnaA regulon, Abh regulon

Gene
Coordinates
2,267,346  2,269,463
The protein
Protein family
ABC transporter superfamily (according to UniProt)
Domains
has both a membrane-spanning and an ATP-binding domain PubMed
Peptidase C39 domain (aa 12-138) (according to UniProt)
ABC transmembrane type-1 domain (aa 168-450) (according to UniProt)
ABC transporter domain (aa 483-705) (according to UniProt)
Structure
4RY2 (PDB) (from Clostridium thermocellum, 33% identity) PubMed
P68579 (AlphaFold)
Localization
membrane PubMed
Expression and Regulation
Operons
Genes
sunA-sunT-bdbA-sunS-bdbB
Description
PubMed
Regulation
repressed by Rok-DnaA PubMed
expression starts in the stationary phase PubMed
expression is heterogeneous in the population, this is mediated by AbrB, Rok, and Spo0A PubMed
Regulatory mechanism
Rok: repression, PubMed, in rok regulon
Abh: activation, PubMed, in abh regulon
DnaA: repression, Rok-DnaA PubMed, in dnaA regulon
YvrHb: activation, PubMed, in yvrHb regulon
AbrB: repression, PubMed, in abrB regulon
Additional information
the mRNA is very stable (> 15 min) PubMed
the amount of the mRNA is substantially decreased upon depletion of RNase Y PubMed
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sunA→bdbB

2025-03-02 00:25:53

Jstuelk

115

173a6d1c6c62ab55ab2900d516e97b549076ae97

85D1B8FA2F46C6C22D4D5CAD32F0080E33BACFA0

Biological materials
Mutant
GP3432 (ΔsunT::spec) , available in Jörg Stülke's lab
BKE21470 (sunT::erm  trpC2) available in the Bacillus Genetic Stock Center and in Jörg Stülke's lab PubMed
BKE21470 (sunT::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CAATTTCAATCCCCGCTTTA,  downstream forward: _UP4_TCGGAAAATAAGGAGTATTC
BKK21470 (sunT::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CAATTTCAATCCCCGCTTTA,  downstream forward: _UP4_TCGGAAAATAAGGAGTATTC
References
Reviews
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Original Publications
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260693EE7F5B5CE2A141149D292405E84B7A5FF4

Page visits: 4101

Time of last update: 2025-03-17 01:31:13

Author of last update: Jstuelk