sqhC

sqhC
168

squalene-hopene cyclase, biosynthesis of sporulenes, protection of the spore against oxidative stress

Locus
BSU_19320
Molecular weight
71.05 kDa
Isoelectric point
7.63
Protein length
632 aaSequenceBlast
Gene length
1899 bpSequenceBlast
Function
biosynthesis of sporulenes
Product
squalene-hopene cyclase
Essential
no
Synonyms
sqhC
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1657 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
2,102,168  2,104,066
The protein
Catalyzed reaction/ biological activity
sporulenol --> H2O + tetraprenyl-β-curcumene (according to UniProt)
production of sporulenes, polycyclic terpenoid lipids PubMed
protection of the spore against oxidative stress PubMed
Protein family
terpene cyclase/mutase family (single member, according to UniProt)
Structure
2SQC (PDB) (from Alicyclobacillus acidocaldarius, 32% identity) PubMed
Q796C3 (AlphaFold)
Localization
surrounds the forespores PubMed
Expression and Regulation
Operons
Genes
sqhC-sodF
Description
PubMed
Regulation
expressed during sporulation in the mother cell PubMed
Sigma factors
SigE: sigma factor, PubMed, in sigE regulon
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sqhC→sodF

2025-03-10 06:11:16

ghost

82

6fa4c70048aebc58f3cffd6e248603b84d1b4262

DF3BA7099188F609C6B2A0A09963B06207F9360B

Biological materials
Mutant
BKE19320 (sqhC::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATCACGCTCAACTCCTTCA,  downstream forward: _UP4_GATTCTATTGAAAAGGAGAC
BKK19320 (sqhC::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATCACGCTCAACTCCTTCA,  downstream forward: _UP4_GATTCTATTGAAAAGGAGAC
References
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24EB23F594F2B0EEA2E055857BA14FD9E361E0FD

Page visits: 2908

Time of last update: 2025-03-16 16:01:53

Author of last update: Melvin.boenninger