dltB
168

D-alanine transfer from DltC to undecaprenol-phosphate, alanylation of teichoic acid provides some resistance against positively charged antimicrobial peptides

Locus

BSU_38510

Molecular weight

46.58 kDa

Isoelectric point

9.94

Protein length

395 aaSequenceBlast

Gene length

1188 bpSequenceBlast

Function

biosynthesis of teichoic acid

Product

D-alanine transfer from DltC to undecaprenol-phosphate

Essential

Synonyms

dltB, ipa-4r

Outlinks

BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Hide small RNAsZoom:

Categories containing this gene/protein

Cellular processes, Cell envelope and cell division, Cell wall synthesis, Biosynthesis of teichoic acid

Cellular processes, Transporters, Transporters/ other, Other transporters

Metabolism, Additional metabolic pathways, Biosynthesis of cell wall components, Biosynthesis of teichoic acid

Lifestyles, Coping with stress, Cell envelope stress proteins (controlled by SigM, V, W, X, Y)

Groups of genes, Membrane proteins

List of homologs in different organisms, belongs to COG1696 (Galperin et al., 2021)

This gene is a member of the following regulons

SigM regulon, SigD regulon, SigX regulon, Spo0A regulon, Stringent response, YvrHb regulon, SigV regulon

Gene

Coordinates

3,953,783 3,954,970

Phenotypes of a mutant

more sensitive to nisin PubMed

The protein

Protein family

Membrane-bound acyltransferase family (single member, according to UniProt)

Structure

6BUI (PDB) (from Streptococcus thermophilus) PubMed

6BUG (PDB) (DtlB-DltC complex from Streptococcus thermophilus) PubMed

6BUH (PDB) (DtlB-DltC complex from Streptococcus thermophilus) PubMed

P39580 (AlphaFold)

Localization

cytoplasma membrane PubMed

Expression and Regulation

Operons

Genes

dltX-dltA-dltB-dltC-dltD-dltE

Description

PubMed

Regulation

expression is reduced in a SigV mutant PubMed

the mRNA is processed between dltX and dltA by RNase Y, this requires the RicA-RicF-RicT complex PubMed

Regulatory mechanism

YvrHb: activation, PubMed, in yvrHb regulon

Spo0A: repression, PubMed, in spo0A regulon

stringent response: negative regulation, in stringent response

Sigma factors

SigD: sigma factor, PubMed, in sigD regulon

SigM: sigma factor, PubMed, in sigM regulon

SigX: sigma factor, PubMed, in sigX regulon

SigV: sigma factor, PubMed, in sigV regulon

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Biological materials

Mutant

BKE38510 (dltB::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CGTCATACAAGAACCTCTTC, downstream forward: _UP4_CACCATTAAAGGAGATTAGA

BKK38510 (dltB::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CGTCATACAAGAACCTCTTC, downstream forward: _UP4_CACCATTAAAGGAGATTAGA

References

Reviews

Original Publications

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Time of last update: 2025-03-16 11:39:49

Author of last update: Jstuelk

dltB 168

dltB
168