dltB

dltB
168

D-alanine transfer from DltC to undecaprenol-phosphate, alanylation of teichoic acid provides some resistance against positively charged antimicrobial peptides

Locus
BSU_38510
Molecular weight
46.58 kDa
Isoelectric point
9.94
Protein length
395 aaSequenceBlast
Gene length
1188 bpSequenceBlast
Function
biosynthesis of teichoic acid
Product
D-alanine transfer from DltC to undecaprenol-phosphate
Essential
no
Synonyms
dltB, ipa-4r
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1696 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,953,783  3,954,970
Phenotypes of a mutant
more sensitive to nisin PubMed
The protein
Protein family
Membrane-bound acyltransferase family (single member, according to UniProt)
Structure
6BUI (PDB) (from Streptococcus thermophilus) PubMed
6BUG (PDB) (DtlB-DltC complex from Streptococcus thermophilus) PubMed
6BUH (PDB) (DtlB-DltC complex from Streptococcus thermophilus) PubMed
P39580 (AlphaFold)
Localization
cytoplasma membrane PubMed
Expression and Regulation
Operons
Genes
dltX-dltA-dltB-dltC-dltD-dltE
Description
PubMed
Regulation
expression is reduced in a SigV mutant PubMed
the mRNA is processed between dltX and dltA by RNase Y, this requires the RicA-RicF-RicT complex PubMed
Regulatory mechanism
YvrHb: activation, PubMed, in yvrHb regulon
Spo0A: repression, PubMed, in spo0A regulon
stringent response: negative regulation, in stringent response
Sigma factors
SigD: sigma factor, PubMed, in sigD regulon
SigM: sigma factor, PubMed, in sigM regulon
SigX: sigma factor, PubMed, in sigX regulon
SigV: sigma factor, PubMed, in sigV regulon
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dltX→dltE

2025-03-16 15:57:21

Jstuelk

133

63d2b4db0f70a01e2ae028dbd1af243776b4151a

0645FBFBF0B41CCF60F55D60BCBA00E9E016D681

Biological materials
Mutant
BKE38510 (dltB::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CGTCATACAAGAACCTCTTC,  downstream forward: _UP4_CACCATTAAAGGAGATTAGA
BKK38510 (dltB::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CGTCATACAAGAACCTCTTC,  downstream forward: _UP4_CACCATTAAAGGAGATTAGA
References
Reviews
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Original Publications
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1B9BAEBE029BE9D4AD7E49C38B1E6DB5E8F4D4D3

Page visits: 5038

Time of last update: 2025-03-17 01:31:13

Author of last update: Jstuelk