yabM

yabM
168

may function in a previously observed alternate pathway for peptidoglycan strand synthesis

Locus
BSU_00570
Molecular weight
57.19 kDa
Isoelectric point
9.62
Protein length
532 aaSequenceBlast
Gene length
1599 bpSequenceBlast
Function
alternate pathway for peptidoglycan strand synthesis
Product
unknown
Essential
no
Synonyms
yabM
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG5841 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
64,817 → 66,415
Phenotypes of a mutant
mutants lacking YabM exhibit sensitivity to moenomycin, an antibiotic that blocks peptidoglycan polymerization by class A penicillin-binding proteins PubMed
inactivation suppresses the essentiality of mbl PubMed
The protein
Catalyzed reaction/ biological activity
may function in a previously observed alternate pathway for peptidoglycan strand synthesis PubMed
Protein family
Polysaccharide synthase family (according to UniProt)
MOP exporter family
Structure
P37555 (AlphaFold)
Paralogous protein(s)
MurJ, YkvU, SpoVB
Localization
cell membrane (according to UniProt)
Expression and Regulation
Operons
Genes
yabM-yabN-rqcP-yabP-shfA-divIC-yabR
Description
PubMed
Regulation
expressed during sporulation (SigE) PubMed
Sigma factors
SigM: sigma factor, PubMed, in sigM regulon
SigE: sigma factor, PubMed, in sigE regulon
SigW: sigma factor, PubMed, in sigW regulon
SigD: sigma factor, PubMed, in sigD regulon
SigX: sigma factor, PubMed, in sigX regulon
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yabM→yabR

2025-03-14 21:01:33

Jstuelk

116

93952be38722510f984794e138450cd80a9f7d48

0CF3909333400A3BFE18E32016883124FFC3D75B

Biological materials
Mutant
MGNA-B914 (yabM::erm), available at the NBRP B. subtilis, Japan
BKE00570 (ΔyabM::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATCCAAAAGCTCCTTCCCA,  downstream forward: _UP4_AAATTCATGAGAAGGAGAGA
BKK00570 (ΔyabM::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATCCAAAAGCTCCTTCCCA,  downstream forward: _UP4_AAATTCATGAGAAGGAGAGA
References
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D6B1837075ECBEE1FEAC704DDB6795336092897F

Page visits: 4149

Time of last update: 2025-03-15 16:44:16

Author of last update: Jstuelk