alsS
168
acetolactate synthase
Locus
BSU_36010
Molecular weight
61.95 kDa
Isoelectric point
5.16
Function
overflow metabolism
Product
acetolactate synthase
Essential
no
E.C.
2.2.1.6
Synonyms
alsS
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0028 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
3,709,628 → 3,711,340
The protein
Catalyzed reaction/ biological activity
H+ + 2 pyruvate --> (2S)-2-acetolactate + CO2 (according to UniProt)
Protein family
TPP enzyme family (according to UniProt)
Structure
4RJJ (PDB) (complex wit TPP) PubMed
Paralogous protein(s)
Expression and Regulation
Operons
Description
Regulation
Regulatory mechanism
stringent response: positive regulation, due to presence of adenines at +1 and +2 positions of the transcript PubMed, in stringent response
Sigma factors
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Biological materials
Mutant
LacZ fusion
pGP3327 (cat, based on pAC5]), available in Jörg Stülke's lab
References
Reviews
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Original Publications
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Time of last update: 2025-03-17 01:31:11
Author of last update: Jstuelk