ykpA

ykpA
168

translation factor, housekeeping subfamily F ABC ATPase, prevents ribosome stalling at charged motifs

Locus
BSU_14430
Molecular weight
60.88 kDa
Isoelectric point
4.98
Protein length
540 aaSequenceBlast
Gene length
1623 bpSequenceBlast
Function
prevention of ribosome stalling
Product
housekeeping subfamily F ABC ATPase
Essential
no
Synonyms
ykpA
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0488 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
1,512,373  1,513,995
The protein
Catalyzed reaction/ biological activity
promotes translation of otherwise difficult positively or negatively charged amino acid stretches PubMed
Protein family
ABC transporter superfamily (according to UniProt)
ABCF ATPase subfamily PubMed
Domains
2 ABC transporter domains (aa 2-252, aa 320-537) (according to UniProt)
Structure
3J5S (PDB) (EttA from E. coli, 33% identity) PubMed
4FIN (PDB) (EttA from E. coli, 33% identity) PubMed
O31716 (AlphaFold)
Paralogous protein(s)
YfmM, YfmR, YdiF
Expression and Regulation
Operons
Genes
ykpA
Description
PubMed
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ykpA

2025-03-01 23:00:04

Jstuelk

82

d46d7c78964b64245215f3dbaa93d21d0da28714

19131ABEDBDE935AAB2D2E20061513BB4E99D8C3

Genes
ykpA-panG
Description
PubMed
Open in new tab

ykpA→panG

2025-03-10 16:56:28

Jstuelk

90

ce96627e6bc3eef0cadea77f88cbe87d581da2c6

A36C5D7B9D14E75C8D85182AA49F8893F8382B7B

Biological materials
Mutant
MGNA-B352 (ykpA::erm), available at the NBRP B. subtilis, Japan
BKE14430 (ykpA::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATTTATTATCCTCCATCAT,  downstream forward: _UP4_TAAAAAAGCAGAGATTTCTC
BKK14430 (ykpA::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATTTATTATCCTCCATCAT,  downstream forward: _UP4_TAAAAAAGCAGAGATTTCTC
References
Reviews
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Original Publications
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2F79DB15D359A127C2D833CC0465E18E1725F539

Page visits: 2108

Time of last update: 2025-03-09 16:34:07

Author of last update: Jstuelk