rapH

rapH
168

response regulator aspartate phosphatase, dephosphorylates Spo0F-P, control of the phosphorelay, control of ComA activity

Locus
BSU_06830
Molecular weight
49.96 kDa
Isoelectric point
6.12
Protein length
376 aaSequenceBlast
Gene length
1131 bpSequenceBlast
Function
control of sporulation initiation and ComA activity
Product
response regulator aspartate phosphatase
Essential
no
Synonyms
rapH, yeeH, yzqA
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms

This gene is a member of the following regulons

Gene
Coordinates
750,959 → 752,089
The protein
Catalyzed reaction/ biological activity
binds to and thereby inhibits ComA activity PubMed
RapH dephosphorylates Spo0F-P and thereby controls the phosphorelay PubMed
in addition to dephosphorylating Spo0F, RapH can antagonize sporulation by sterically blocking phosphoryl transfer to and from Spo0F  PubMed
Protein family
RAP family (according to UniProt)
Domains
six tetratrichopeptide repeats (according to UniProt)
Structure
3Q15 (PDB) (RapH-Spo0F complex) PubMed
Effectors of protein activity
interaction with PhrH inhibits dephosphorylation of Spo0F and sequestration of ComA by RapH PubMed
Expression and Regulation
Operons
Genes
rapH-phrH
Description
PubMed
Regulation
''rapH'': repressed by RghR PubMed
Regulatory mechanism
RghR: repression, PubMed, in rghR regulon
ComK: activation, PubMed, in comK regulon
AbrB: repression, PubMed, in abrB regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
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rapH→phrH

2025-03-18 02:12:33

ghost

105

afdfd4e58aa462c1f34c8519b1214c943fc47156

3178B428D9699AC0C49193C0A58CC78CB3717A7F

Biological materials
Mutant
MGNA-A013 (rapH::erm), available at the NBRP B. subtilis, Japan
BKE06830 (ΔrapH::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CAACGGCTTCCCTCCTTCTC,  downstream forward: _UP4_GATATTCTAAAAGGAGAGTG
BKK06830 (ΔrapH::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CAACGGCTTCCCTCCTTCTC,  downstream forward: _UP4_GATATTCTAAAAGGAGAGTG
References
Reviews
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Original Publications
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BA85E2C2E2A6B76FAFA31EBDBF466324C9B021C8

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Time of last update: 2025-03-26 13:10:14

Author of last update: Jstuelk