tetB

tetB
168

tetracycline exporter, multifunctional tetracycline/Na+ resistance protein

Locus
BSU_40770
Molecular weight
49.59 kDa
Isoelectric point
9.54
Protein length
458 aaSequenceBlast
Gene length
1377 bpSequenceBlast
Function
resistance to tetracyclin
Product
metal-tetracycline/H+ antiporter
Essential
no
Synonyms
tetB, tetA, tetA(L)
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG2814 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
4,187,681  4,189,057
The protein
Catalyzed reaction/ biological activity
export of tetracyclin (according to Uniprot)
Protein family
major facilitator superfamily (according to UniProt)
TCR/Tet family (according to UniProt)
Structure
P23054 (AlphaFold)
Localization
cell membrane (according to UniProt)
Expression and Regulation
Operons
Genes
tetL-tetB
Description
(according to DBTBS) null
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
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tetL→tetB

2025-03-09 17:57:50

ghost

99

63c9a5af3eca26ece65b2cd2d340c7272e31a94e

A09189BCE1C3051FC5DFEEAC90EE8300EB8336CB

Biological materials
Mutant
GP2080 (''tetB::cat''), available in Jörg Stülke's lab
GP2081 (''tetB::ermC''), available in Jörg Stülke's lab
BKE40770 (tetB::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CACAATTTCCCCTCCATTAA,  downstream forward: _UP4_TAAATGAGTGAAAGGATCAA
BKK40770 (tetB::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CACAATTTCCCCTCCATTAA,  downstream forward: _UP4_TAAATGAGTGAAAGGATCAA
Labs working on this gene/protein
David Bechhofer, Mount Sinai School, New York, USA Homepage
References
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4B900A64A96696F48BB0C2DC3B0884CD2F5E298B

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Time of last update: 2025-03-14 05:56:29

Author of last update: Jstuelk