secDF

secDF
168

preprotein translocase subunit (ATPase)

Locus
BSU_27650
Molecular weight
81.47 kDa
Isoelectric point
9.52
Protein length
737 aaSequenceBlast
Gene length
2214 bpSequenceBlast
Function
protein secretion
Product
preprotein translocase subunit (ATPase)
Essential
no
Synonyms
secDF, secF, secD
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0342 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
2,826,900 → 2,829,113
Phenotypes of a mutant
reduced protein secretion PubMed
defective in Swarming motility (prolonged period of immotility prior to Swarming) PubMed
The protein
Protein family
N-terminal part: SecD/SecF family (single member, according to UniProt)
C-terminal part: SecD/SecF family (single member, according to UniProt)
Structure
5XAN (PDB) (from Deinococcus radiodurans, 32% identity) PubMed
O32047 (AlphaFold)
Localization
membrane PubMed
Expression and Regulation
Operons
Genes
comN-secDF
Description
PubMed
Sigma factors
SigM: sigma factor, PubMed, in sigM regulon
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comN->secDF

2025-03-15 04:16:12

Bzhu

76

c394b904979c4c093d9b6e81901fe4d43db37ff3

4A6269F7B3E939FAE1E8CF427D8A743BEE07648E

Biological materials
Mutant
MGNA-B519 (yrvB::erm), available at the NBRP B. subtilis, Japan
SM-GN3 (secDF-spc), available in Anne Galinier's and Boris Görke's labs
BKE27650 (ΔsecDF::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATTATGTATATCCTCCCTT,  downstream forward: _UP4_TAAAAAATATCAGGCTGTCC
BKK27650 (ΔsecDF::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATTATGTATATCCTCCCTT,  downstream forward: _UP4_TAAAAAATATCAGGCTGTCC
References
Reviews
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Original Publications
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F0E7B6E000A5B06C9023C76F21551E754C8C45BA

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Time of last update: 2025-03-15 00:23:47

Author of last update: Jstuelk