phrF

phrF
168

response regulator aspartate phosphatase (RapF) regulator, antagonizes the RapF-ComA interaction

Locus
BSU_37470
Molecular weight
4.07 kDa
Isoelectric point
10.24
Protein length
39 aaSequenceBlast
Gene length
120 bpSequenceBlast
Function
control of ComA activity
Product
phosphatase (RapF) regulator
Essential
no
E.C.
null
Synonyms
phrF, ywhI
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms

This gene is a member of the following regulons

Gene
Coordinates
3,847,130 → 3,847,249
The protein
Catalyzed reaction/ biological activity
binds to RapF, this results in the inability of RapF to interact with ComA PubMed
Protein family
phr family (according to UniProt)
Structure
P71001 (AlphaFold)
Expression and Regulation
Operons
Genes
rapF-phrF
Description
PubMed
Regulation
PhrF accumulates at high cell density
Regulatory mechanism
CcpA: repression, PubMed, in ccpA regulon
ComA: activation, PubMed, in comA regulon
Sigma factors
SigH: sigma factor, PubMed, in sigH regulon
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rapF→phrF

2025-03-15 01:27:34

ghost

99

caaf58cf3ca24000725b4e5af0da77551dda5a5a

010F63D4BF5DE15B6446EA3923DABA1AD5BB01DD

Genes
phrF
Description
PubMed
Regulation
PhrF accumulates at high cell density
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phrF

2025-03-10 04:43:52

ghost

50

3a465f6b86242be8dd89892b04f668d99c079a03

4630C094A8458FABE37D63FB2F26BC7230337DE1

Biological materials
Mutant
BKE37470 (ΔphrF::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_TAGAGCCAGACAAGAGAGTA,  downstream forward: _UP4_TAACCGCCGTCCATCGGCGG
BKK37470 (ΔphrF::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_TAGAGCCAGACAAGAGAGTA,  downstream forward: _UP4_TAACCGCCGTCCATCGGCGG
References
Reviews
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Original Publications
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AEBEDF43C56A9A54716D781D062067B69818FAF4

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Time of last update: 2025-03-15 19:16:16

Author of last update: Jstuelk