dltD
168

D-alanine transfer from undecaprenol-phosphate to the poly(glycerophosphate) chain, alanylation of teichoic acid provides some resistance against positively charged antimicrobial peptides

Locus

BSU_38530

Molecular weight

44.65 kDa

Isoelectric point

9.86

Protein length

392 aaSequenceBlast

Gene length

1179 bpSequenceBlast

Function

biosynthesis of teichoic acid

Product

D-alanine transfer from undecaprenol-phosphate to the poly(glycerophosphate) chain

Essential

Synonyms

dltD, ipa-2r

Outlinks

BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Hide small RNAsZoom:

Categories containing this gene/protein

Cellular processes, Cell envelope and cell division, Cell wall synthesis, Biosynthesis of teichoic acid

Metabolism, Additional metabolic pathways, Biosynthesis of cell wall components, Biosynthesis of teichoic acid

Lifestyles, Coping with stress, Cell envelope stress proteins (controlled by SigM, V, W, X, Y)

Groups of genes, Membrane proteins

List of homologs in different organisms, belongs to COG3966 (Galperin et al., 2021)

This gene is a member of the following regulons

SigM regulon, SigD regulon, SigX regulon, Spo0A regulon, Stringent response, YvrHb regulon, SigV regulon

Gene

Coordinates

3,955,223 → 3,956,401

Phenotypes of a mutant

more sensitive to nisin PubMed

The protein

Protein family

DltD family (single member, according to UniProt)

Structure

3BMA (PDB) (from Streptococcus pneumoniae, 26% identity)

P39578 (AlphaFold)

Localization

cell membrane (according to UniProt)

Expression and Regulation

Operons

Genes

dltX-dltA-dltB-dltC-dltD-dltE

Description

PubMed

Regulation

expression is reduced in a SigV mutant PubMed

the mRNA is processed between dltX and dltA by RNase Y, this requires the RicA-RicF-RicT complex PubMed

Regulatory mechanism

YvrHb: activation, PubMed, in yvrHb regulon

Spo0A: repression, PubMed, in spo0A regulon

stringent response: negative regulation, in stringent response

Sigma factors

SigD: sigma factor, PubMed, in sigD regulon

SigM: sigma factor, PubMed, in sigM regulon

SigX: sigma factor, PubMed, in sigX regulon

SigV: sigma factor, PubMed, in sigV regulon

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Biological materials

Mutant

BKE38530 (ΔdltD::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_TGGACCGAAAAAACGCTTTT, downstream forward: _UP4_TGAGCATCTCATAGGACGCG

BKK38530 (ΔdltD::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_TGGACCGAAAAAACGCTTTT, downstream forward: _UP4_TGAGCATCTCATAGGACGCG

References

Reviews

Original Publications

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Time of last update: 2025-03-17 15:24:23

Author of last update: Jstuelk

dltD 168

dltD
168