dltD

dltD
168

D-alanine transfer from undecaprenol-phosphate to the poly(glycerophosphate) chain, alanylation of teichoic acid provides some resistance against positively charged antimicrobial peptides

Locus
BSU_38530
Molecular weight
44.65 kDa
Isoelectric point
9.86
Protein length
392 aaSequenceBlast
Gene length
1179 bpSequenceBlast
Function
biosynthesis of teichoic acid
Product
D-alanine transfer from undecaprenol-phosphate to the poly(glycerophosphate) chain
Essential
no
Synonyms
dltD, ipa-2r
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG3966 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,955,223 → 3,956,401
Phenotypes of a mutant
more sensitive to nisin PubMed
The protein
Protein family
DltD family (single member, according to UniProt)
Structure
3BMA (PDB) (from Streptococcus pneumoniae, 26% identity)
P39578 (AlphaFold)
Localization
cell membrane (according to UniProt)
Expression and Regulation
Operons
Genes
dltX-dltA-dltB-dltC-dltD-dltE
Description
PubMed
Regulation
expression is reduced in a SigV mutant PubMed
the mRNA is processed between dltX and dltA by RNase Y, this requires the RicA-RicF-RicT complex PubMed
Regulatory mechanism
YvrHb: activation, PubMed, in yvrHb regulon
Spo0A: repression, PubMed, in spo0A regulon
stringent response: negative regulation, in stringent response
Sigma factors
SigD: sigma factor, PubMed, in sigD regulon
SigM: sigma factor, PubMed, in sigM regulon
SigX: sigma factor, PubMed, in sigX regulon
SigV: sigma factor, PubMed, in sigV regulon
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dltX→dltE

2025-03-16 15:57:21

Jstuelk

133

63d2b4db0f70a01e2ae028dbd1af243776b4151a

0645FBFBF0B41CCF60F55D60BCBA00E9E016D681

Biological materials
Mutant
BKE38530 (ΔdltD::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_TGGACCGAAAAAACGCTTTT,  downstream forward: _UP4_TGAGCATCTCATAGGACGCG
BKK38530 (ΔdltD::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_TGGACCGAAAAAACGCTTTT,  downstream forward: _UP4_TGAGCATCTCATAGGACGCG
References
Reviews
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Original Publications
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D178EC8A1FF22C99C437E01FC4843C5176564992

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Time of last update: 2025-03-17 20:50:16

Author of last update: Jstuelk