lutR

lutR
168

transcriptional repressor (GntR family) of the lutA-lutB-lutC operon and of lutP

Locus
BSU_34180
Molecular weight
19.50 kDa
Isoelectric point
4.84
Protein length
219 aaSequenceBlast
Gene length
660 bpSequenceBlast
Function
control of lactate utilization
Product
transcriptional repressor, (GntR family)
Essential
no
Synonyms
lutR, yvfI
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

List of homologs in different organisms, belongs to COG2186 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,509,831 → 3,510,490
The protein
Catalyzed reaction/ biological activity
transcriptional repressor of the lutA-lutB-lutC operon PubMed
Protein family
GntR family of transcription factors
Domains
HTH gntR-type domain (aa 1-56) (according to UniProt)
Structure
6AZ6 (PDB) (GntR from Streptococcus agalactiae, 30% identity) PubMed
O07007 (AlphaFold)
Effectors of protein activity
lactate acts as molecular inducer PubMed
Expression and Regulation
Operons
Genes
lutR
Description
PubMed
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
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lutR

2025-02-27 11:01:05

Bzhu

76

f1dc528fccd88d8360faa91099cb54f85aca4bc6

E77BC538D111921704345E18D5A6303A429BB66F

Biological materials
Mutant
MGNA-B607 (yvfI::erm), available at the NBRP B. subtilis, Japan
TEK1 lutR::Tn10::spc PubMed
BKE34180 (ΔlutR::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATATCTAATAGGGCATCCG,  downstream forward: _UP4_TAACCAACTCATTTCCCGGG
BKK34180 (ΔlutR::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATATCTAATAGGGCATCCG,  downstream forward: _UP4_TAACCAACTCATTTCCCGGG
Expression vectors
pQE60-lutR (His-tag) PubMed
LacZ fusion
TEK7 lutR::lacZ::erm PubMed
Labs working on this gene/protein
Richard Losick, Harvard Univ., Cambridge, USA homepage
Ayten Katatas, Istanbul Technical University, Istanbul, Turkey x
References
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E6F3BAC5875A16D8D75B2AD21447C14DD17B3DA6

Page visits: 7545

Time of last update: 2025-03-17 01:30:58

Author of last update: Melvin.boenninger