pth

pth
168

peptidyl-tRNA hydrolase, general stress protein

Locus
BSU_00530
Molecular weight
20.73 kDa
Isoelectric point
5.58
Protein length
Gene length
Function
ribosome-associated quality control
Product
peptidyl-tRNA hydrolase
Essential
yes
E.C.
3.1.1.29
Synonyms
spoVC

Genomic Context

List of homologs in different organisms, belongs to COG0193 (Galperin et al., 2021)

This gene is a member of the following regulons

SigB regulon

Gene
Coordinates
59,504 → 60,070
Phenotypes of a mutant
essential PubMed
The protein
Catalyzed reaction/ biological activity
H2O + N-acyl-L-α-aminoacyl-tRNA --> N-acyl-L-amino acid + H+ + tRNA (according to UniProt)
Protein family
PTH family (single member, according to UniProt)
Structure
4YLY (PDB) (from Staphylococcus aureus, 52.9% identity) PubMed
4QT4 (PDB) (from Streptococcus pyogenes, 48% identity) PubMed
cytoplasm (according to UniProt)
Expression and Regulation
Operons
Genes
Description
Regulation
induced under stress conditions (SigB) PubMed
Sigma factors
SigB: sigma factor, PubMed, in sigB regulon
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ctcfin

2025-03-16 15:44:36

Jstuelk

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References
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Time of last update: 2025-03-16 13:37:58

Author of last update: Jstuelk