pth

pth
168

peptidyl-tRNA hydrolase, general stress protein

Locus
BSU_00530
Molecular weight
20.73 kDa
Isoelectric point
5.58
Protein length
188 aaSequenceBlast
Gene length
567 bpSequenceBlast
Function
ribosome-associated quality control
Product
peptidyl-tRNA hydrolase
Essential
yes
E.C.
3.1.1.29
Synonyms
spoVC
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0193 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
59,504 → 60,070
Phenotypes of a mutant
essential PubMed
The protein
Catalyzed reaction/ biological activity
H2O + N-acyl-L-α-aminoacyl-tRNA --> N-acyl-L-amino acid + H+ + tRNA (according to UniProt)
Protein family
PTH family (single member, according to UniProt)
Structure
4YLY (PDB) (from Staphylococcus aureus, 52.9% identity) PubMed
4QT4 (PDB) (from Streptococcus pyogenes, 48% identity) PubMed
P37470 (AlphaFold)
Localization
cytoplasm (according to UniProt)
Expression and Regulation
Operons
Genes
ctc-pth-fin
Description
PubMed
Regulation
induced under stress conditions (SigB) PubMed
Sigma factors
SigB: sigma factor, PubMed, in sigB regulon
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ctc→fin

2025-03-16 15:44:36

Jstuelk

125

042d8e5a6f42561738123d446c8cdfdcb7b024b0

AF90CE02D929F6F737FC233892E7E08A4B249DEC

References
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Time of last update: 2025-03-17 20:50:16

Author of last update: Jstuelk