pth
168

peptidyl-tRNA hydrolase, general stress protein

Locus

BSU_00530

Molecular weight

20.73 kDa

Isoelectric point

5.58

Protein length

188 aaSequenceBlast

Gene length

567 bpSequenceBlast

Function

ribosome-associated quality control

Product

peptidyl-tRNA hydrolase

Essential

yes

E.C.

3.1.1.29

Synonyms

spoVC

Outlinks

BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Hide small RNAsZoom:

Categories containing this gene/protein

Information processing, Protein synthesis, modification and degradation, Translation, Translation/ other

Information processing, Protein synthesis, modification and degradation, Translation, Ribosome quality control and ribosome rescue

Lifestyles, Coping with stress, General stress proteins (controlled by SigB)

Groups of genes, Essential genes

List of homologs in different organisms, belongs to COG0193 (Galperin et al., 2021)

This gene is a member of the following regulons

SigB regulon

Gene

Coordinates

59,504 → 60,070

Phenotypes of a mutant

essential PubMed

The protein

Catalyzed reaction/ biological activity

H₂O + N-acyl-L-α-aminoacyl-tRNA --> N-acyl-L-amino acid + H⁺ + tRNA (according to UniProt)

Protein family

PTH family (single member, according to UniProt)

Structure

4YLY (PDB) (from Staphylococcus aureus, 52.9% identity) PubMed

4QT4 (PDB) (from Streptococcus pyogenes, 48% identity) PubMed

P37470 (AlphaFold)

Localization

cytoplasm (according to UniProt)

Expression and Regulation

Operons

Genes

ctc-pth-fin

Description

PubMed

Regulation

induced under stress conditions (SigB) PubMed

Sigma factors

SigB: sigma factor, PubMed, in sigB regulon

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References

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Time of last update: 2025-03-16 13:37:58

Author of last update: Jstuelk

pth 168

pth
168