cydA

cydA
168

cytochrome bd ubiquinol oxidase (subunit I), high affinity terminal oxidase

Locus
BSU_38760
Molecular weight
52.13 kDa
Isoelectric point
8.94
Protein length
468 aaSequenceBlast
Gene length
1407 bpSequenceBlast
Function
respiration
Product
cytochrome bd ubiquinol oxidase (subunit I), high affinity terminal oxidase
Essential
no
Synonyms
cydA, yxkK
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1271 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,977,791 → 3,979,197
The protein
Catalyzed reaction/ biological activity
2 ubiquinol + n H+ + O2 --> 2 ubiquinone + n H+ + 2 H2O (according to UniProt)
Protein family
cytochrome ubiquinol oxidase subunit 1 family (with YthA, according to UniProt)
Cofactors
heme b, heme d (according to UniProt)
Structure
5DOQ (PDB) (from Geobacillus thermodenitrificans, 30% identity) PubMed
P94364 (AlphaFold)
Paralogous protein(s)
YthA
Localization
cell membrane (according to Swiss-Prot)
Expression and Regulation
Operons
Genes
cydA-cydB-cydC-cydD
Description
PubMed
Regulation
expressed under anaerobic conditions (ResD) PubMed
Expression
expression is heterogeneous PubMed
Regulatory mechanism
CcpA: repression, in ccpA regulon
Rex: repression, PubMed, in rex regulon
ResD: activation, PubMed, in resD regulon
Sigma factors
SigF: sigma factor, PubMed, in sigF regulon
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cydA→cydD

2025-03-15 16:32:37

Jstuelk

120

B656DC522BB35F8FB6BB0C0BBC86CB05C20AB7C7

80895031322ED50D8EABA337924455145A6261DF

Biological materials
Mutant
MGNA-B745 (cydA::erm), available at the NBRP B. subtilis, Japan
BKE38760 (ΔcydA::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATGCTTTCTCCTCCATTTC,  downstream forward: _UP4_GATCCATTTAGTCAGGAGGT
BKK38760 (ΔcydA::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATGCTTTCTCCTCCATTTC,  downstream forward: _UP4_GATCCATTTAGTCAGGAGGT
LacZ fusion
pGP3879 (kan, based on pAC7]), available in Jörg Stülke's lab
GP4302 (cydA-lacZ::aphA3), available in Jörg Stülke's lab
References
Reviews
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Original Publications
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C0459C0D45E31561D281E016D86CD80DCAF13357

Page visits: 4376

Time of last update: 2025-03-15 20:08:13

Author of last update: Dennis.wicke