lmrA

lmrA
168

transcriptional regulator (TetR family), control of qdoI-yxaH and lmrA-lmrB

Locus
BSU_02680
Molecular weight
20.52 kDa
Isoelectric point
5.03
Protein length
188 aaSequenceBlast
Gene length
567 bpSequenceBlast
Function
regulation of lincomycin resistance
Product
transcriptional regulator
Essential
no
Synonyms
lmrA, lin-2, yccB
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1309 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
290,132  290,698
The protein
Protein family
TetR family
Domains
HTH tetR-type domain (aa 4-64) (according to UniProt)
Structure
1SGM (PDB) (QdoR, 56% identity) PubMed
O34619 (AlphaFold)
Effectors of protein activity
flavonoids such as quercetin serve as inducers, binding results in release from DNA PubMed
Paralogous protein(s)
QdoR
Expression and Regulation
Operons
Genes
lmrA-lmrB
Description
PubMed
Regulation
induced by flavonoids such as quercetin (LmrA)PubMed
Regulatory mechanism
LmrA: repression, PubMed, in lmrA regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
Additional information
the mRNA is substantially stabilized upon depletion of RNase Y PubMed
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lmrA→lmrB

2025-03-08 04:22:43

ghost

113

be7795d98f26be96a984dc95802c21f2dcb1e545

FCA0758D41C878E1059BF369D1C30C97AACB6B0C

Biological materials
Mutant
BKE02680 (lmrA::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATAACATTCCCACCTTACT,  downstream forward: _UP4_TAAAAAAAACGACATACTAC
BKK02680 (lmrA::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATAACATTCCCACCTTACT,  downstream forward: _UP4_TAAAAAAAACGACATACTAC
References
Reviews
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Original Publications
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52D560AA02F0849CB24460A496021560063B2E12

Page visits: 6104

Time of last update: 2025-03-12 06:12:44

Author of last update: Jstuelk