bdbA
168

thiol-disulfide oxidoreductase

Locus

BSU_21460

Molecular weight

16.04 kDa

Isoelectric point

8.34

Protein length

137 aaSequenceBlast

Gene length

414 bpSequenceBlast

Function

oxidative folding of proteins

Product

thiol-disulfide oxidoreductase

Essential

Synonyms

bdbA, yolI

Outlinks

BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

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Categories containing this gene/protein

List of homologs in different organisms, belongs to COG3118 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene

Coordinates

2,266,936 → 2,267,349

The protein

Protein family

Thioredoxin family (according to UniProt)

Domains

Thioredoxin domain (aa 26-136) (according to UniProt)

Structure

P68569 (AlphaFold)

Localization

secreted (according to UniProt)

Expression and Regulation

Operons

Genes

sunA-sunT-bdbA-sunS-bdbB

Description

PubMed

Regulation

repressed by Rok-DnaA PubMed

expression starts in the stationary phase PubMed

expression is heterogeneous in the population, this is mediated by AbrB, Rok, and Spo0A PubMed

Regulatory mechanism

Rok: repression, PubMed, in rok regulon

Abh: activation, PubMed, in abh regulon

DnaA: repression, Rok-DnaA PubMed, in dnaA regulon

YvrHb: activation, PubMed, in yvrHb regulon

AbrB: repression, PubMed, in abrB regulon

Additional information

the mRNA is very stable (> 15 min) PubMed

the amount of the mRNA is substantially decreased upon depletion of RNase Y PubMed

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Biological materials

Mutant

BKE21460 (ΔbdbA::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_TTTCATATAGAATACTCCTT, downstream forward: _UP4_TTTGATAAAAATGGTGATAG

BKK21460 (ΔbdbA::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_TTTCATATAGAATACTCCTT, downstream forward: _UP4_TTTGATAAAAATGGTGATAG

References

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Time of last update: 2025-03-14 14:55:53

Author of last update: Melvin.boenninger

bdbA 168

bdbA
168