srfAD

srfAD
168

surfactin synthetase / competence

Locus
BSU_03520
Molecular weight
27.47 kDa
Isoelectric point
5.22
Protein length
242 aaSequenceBlast
Gene length
729 bpSequenceBlast
Function
antibiotic synthesis
Product
surfactin synthetase / competence
Essential
no
Synonyms
srfAD, comL
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG3208 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
402,388 403,116
The protein
Protein family
thioesterase family (with YneP, according to UniProt)
Structure
2RON (PDB) PubMed
2K2Q (PDB)
Q08788 (AlphaFold)
Localization
cytoplasm (according to Swiss-Prot)
Additional information
belongs to the 100 most abundant proteins PubMed
Expression and Regulation
Operons
Genes
srfAA-srfAB-comS-srfAC-srfAD
Description
PubMed
Regulation
expressed at high cell density (ComA) PubMed
heterogeneous expression, percentage of expressing cells increases during colonization of plant roots PubMed
Regulatory mechanism
PhoP: activation, PubMed, in phoP regulon
CodY: repression, PubMed, in codY regulon
ComA: activation, PubMed, in comA regulon
PerR: activation, PubMed, in perR regulon
Spx: repression, PubMed, in spx regulon
Abh: repression, PubMed, in abh regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
Additional information
A ncRNA is predicted between 'HxlR' and 'SrfAA' PubMed
Open in new tab

srfAA→srfAD

2025-03-15 18:25:03

Jstuelk

152

620D29280C2CC5BBF61DFDE1E763667777B28513

4F5B391B1D8CC1181EDE8EB2DAC874A9B90A39CA

Biological materials
Mutant
BKE03520 (srfAD::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATTGGCTGTCTCCTCCTTT, downstream forward: _UP4_TGATCAAAAGCGGACAGCTT
BKK03520 (srfAD::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATTGGCTGTCTCCTCCTTT, downstream forward: _UP4_TGATCAAAAGCGGACAGCTT
References
Reviews
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Original Publications
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9D0914FC38FFF4028C2BA5970DC87B3A1027E253

Page visits: 4831

Time of last update: 2025-03-15 19:26:40

Author of last update: Jstuelk