ppsD

ppsD
168

plipastatin synthetase

Locus
BSU_18310
Molecular weight
406.42 kDa
Isoelectric point
5.35
Protein length
3603 aaSequenceBlast
Gene length
10812 bpSequenceBlast
Function
production of the antibacterial compound plipastatin
Product
plipastatin synthetase
Essential
no
Synonyms
ppsD
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG4908 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
1,964,045 → 1,974,856
Phenotypes of a mutant
defective in sporulation timing PubMed
The protein
Protein family
ATP-dependent AMP-binding enzyme family (according to UniProt)
Domains
3 Carrier domains (aa 966-1041, aa 1997-2072, aa 3034-3108) (according to UniProt)
Structure
2VSQ (PDB) (termination module of SrfAC, 38% identity) PubMed
Expression and Regulation
Operons
Genes
ppsA-ppsB-ppsC-ppsD-ppsE
Description
PubMed
Regulatory mechanism
AbrB: repression, PubMed, in abrB regulon
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ppsA→ppsE

2025-03-09 16:47:41

ghost

104

c24e95905169206a2bb4f32c2e44eb72392e19bb

53EB981BAF3A634ABF820E4DAD645D458FD52A47

Biological materials
Mutant
BKE18310 (ΔppsD::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATGTTCATGTCTCCTGTCA,  downstream forward: _UP4_ATGCTCAGTTTTCACTAATG
BKK18310 (ΔppsD::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATGTTCATGTCTCCTGTCA,  downstream forward: _UP4_ATGCTCAGTTTTCACTAATG
References
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E73D9F1A8F54DAD4B2056CABBE580D7AD36CB042

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Time of last update: 2025-03-15 03:29:59

Author of last update: Jstuelk