Difference between revisions of "WalK"
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| − | * '''Description:''' [[two-component systems|two-component]] sensor kinase, controls cell wall metabolism <br/><br/> | + | * '''Description:''' [[two-component systems|two-component]] sensor kinase, controls cell wall metabolism, co-ordinates cell wall remodelling with [[cell division]] by controlling the transcription of genes for autolysins and their inhibitors <br/><br/> |
{| align="right" border="1" cellpadding="2" | {| align="right" border="1" cellpadding="2" | ||
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|style="background:#ABCDEF;" align="center"| '''Product''' || [[two-component systems|two-component]] sensor kinase (OmpR family) | |style="background:#ABCDEF;" align="center"| '''Product''' || [[two-component systems|two-component]] sensor kinase (OmpR family) | ||
|- | |- | ||
| − | |style="background:#ABCDEF;" align="center"|'''Function''' || control of cell wall metabolism | + | |style="background:#ABCDEF;" align="center"|'''Function''' || control of [[cell wall metabolism]] |
|- | |- | ||
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 69 kDa, 4.775 | |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 69 kDa, 4.775 | ||
| Line 82: | Line 82: | ||
* '''Effectors of protein activity:''' | * '''Effectors of protein activity:''' | ||
| − | * '''Interactions:''' [[WalK]]-[[WalR]] | + | * '''Interactions:''' [[WalK]]-[[WalR]], [[WalK]]-[[YycH]] {{PubMed|21219466}}, [[WalK]]-[[YycI]] {{PubMed|21219466}}, [[WalK]]-[[DivIB]] {{PubMed|21219466}}, [[WalK]]-[[FtsL]] {{PubMed|21219466}}, [[WalK]]-[[PbpB]] {{PubMed|21219466}} |
| − | * '''Localization:''' cell membrane | + | * '''Localization:''' cell membrane {{PubMed|21219466}}, part of the division septum in growing cells, interacts with the [[divisome]] [http://www.ncbi.nlm.nih.gov/sites/entrez/18573169 PubMed] |
=== Database entries === | === Database entries === | ||
| Line 133: | Line 133: | ||
==Original Publications== | ==Original Publications== | ||
| − | <pubmed>18573169,17350627,17827301,9829949,17581128,10878122,16030236,12950927,18408157, 19342776 20057515 20059685 20167622 </pubmed> | + | <pubmed>18573169,17350627,17827301,9829949,17581128,10878122,16030236,12950927,18408157, 19342776 20057515 20059685 20167622 21219466 </pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 10:04, 12 January 2011
- Description: two-component sensor kinase, controls cell wall metabolism, co-ordinates cell wall remodelling with cell division by controlling the transcription of genes for autolysins and their inhibitors
| Gene name | walK |
| Synonyms | yycG |
| Essential | yes PubMed |
| Product | two-component sensor kinase (OmpR family) |
| Function | control of cell wall metabolism |
| MW, pI | 69 kDa, 4.775 |
| Gene length, protein length | 1833 bp, 611 aa |
| Immediate neighbours | yycH, walR |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
Categories containing this gene/protein
cell wall/ other, protein modification, transcription factors and their control, essential genes, membrane proteins, phosphoproteins
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU40400
Phenotypes of a mutant
essential PubMed
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: autophosphorylation, phosphorylation of WalR
- Protein family: two-component sensor kinase of the OmpR family
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains: two transmembrane segments, C-terminal histidine phosphotransferase domain
- Modification: autophosphorylation on a His residue
- Cofactor(s):
- Effectors of protein activity:
- Interactions: WalK-WalR, WalK-YycH PubMed, WalK-YycI PubMed, WalK-DivIB PubMed, WalK-FtsL PubMed, WalK-PbpB PubMed
- Localization: cell membrane PubMed, part of the division septum in growing cells, interacts with the divisome PubMed
Database entries
- Structure:
- UniProt: Q45614
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Regulation: expressed during vegetative growth, repressed during stationary phase PubMed
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Reviews
Original Publications
