yvrC
168
[wiki|ABC transporter] (binding protein) for cobalamin
locus
BSU_33180
Molecular weight
34.08 kDa
pI
4.93
function
uptake of cobalamin
product
[wiki|ABC transporter] (binding protein)
essential
no
synonyms
yvrC
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0614 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
3,403,493 → 3,404,437
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The protein
Protein family
[wiki|Bacterial solute-binding protein 8 family] (according to UniProt)
[wiki|Domains]
[wiki|Fe/B12 periplasmic-binding domain] (aa 59-311) (according to UniProt)
Structure
[PDB|4M7O] (from Staphylococcus epidermidis, 45% identity)
[AF|O34805]
[wiki|Localization]
cell membrane (according to UniProt)
Expression and Regulation
Operons
genes
[gene|C76265F521D9A153F28AC6BACD935CC20DEA5D9C|yvrC]-[gene|1DC4A3D7E93677B0EAD15F43C80E50FD98527EBC|yvrB]-[gene|128EBAE9C14C7BB75173DF912853A6FCE86ABCE4|yvrA]-[gene|468D9141EAC78556C9F6C564875F70EC43E60C1C|yvqK]
regulation
expression is decreased in the presence of cobalamin (vitamin B12) ([wiki|B12 riboswitch]) [Pubmed|14704351]
regulatory mechanism
B12 riboswitch: RNA switch, upon binding of B12 [Pubmed|14704351], in [regulon|other_regulator:B12 riboswitch|B12 riboswitch]
Biological materials
Mutant
MGNA-B045 (yvrC::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1044 NBRP B. subtilis, Japan]
BKE33180 (Δ[gene|C76265F521D9A153F28AC6BACD935CC20DEA5D9C|yvrC]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE33180 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATAATCTTTTCCTCCTAAA, downstream forward: _UP4_CGTCTGATCGAAGGGGTCGA
BKK33180 (Δ[gene|C76265F521D9A153F28AC6BACD935CC20DEA5D9C|yvrC]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK33180 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATAATCTTTTCCTCCTAAA, downstream forward: _UP4_CGTCTGATCGAAGGGGTCGA
References
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Time of last update: 2024-12-01 23:31:33
Author of last update: Jstuelk