ung
168
uracil-DNA glycosylase
locus
BSU_37970
Molecular weight
25.90 kDa
pI
8.78
function
DNA repair
product
uracil-DNA glycosylase
essential
no
synonyms
ung, ipa-57d, ywdG
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0692 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
3,897,685 → 3,898,362
Phenotypes of a mutant
increased mutation rates [Pubmed|22056936]
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The protein
Catalyzed reaction/ biological activity
removes uracil preferentially from single-stranded DNA over double-stranded DNA, exhibiting higher preference for U:G than U:A mismatches [Pubmed|21542855]
Protein family
uracil-DNA glycosylase (UDG) superfamily (single member, according to UniProt)
Structure
[PDB|3A7N] (from ''Mycobacterium tuberculosis'', 42% identity) [Pubmed|20693660]
[AF|P39615]
[wiki|Localization]
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
genes
[gene|DC73C11C3C54D35B2D9A0A28666A29E36451E7F8|ung]
description
[Pubmed|9353933]
regulation
expressed throughout growth and staionary phase [Pubmed|22056936]
genes
[gene|1DA87B205F2E201DE027209620110D043AF8A6AF|ywdF]-[gene|DC73C11C3C54D35B2D9A0A28666A29E36451E7F8|ung]
description
[Pubmed|22383849]
Biological materials
Mutant
BKE37970 (Δ[gene|DC73C11C3C54D35B2D9A0A28666A29E36451E7F8|ung]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE37970 BGSC], [Pubmed|28189581], upstream reverse: _UP1_AAGCTGTTTCAAGATTCAGG, downstream forward: _UP4_TAAAAAGCGCAGGTGATCTG
BKK37970 (Δ[gene|DC73C11C3C54D35B2D9A0A28666A29E36451E7F8|ung]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK37970 BGSC], [Pubmed|28189581], upstream reverse: _UP1_AAGCTGTTTCAAGATTCAGG, downstream forward: _UP4_TAAAAAGCGCAGGTGATCTG
References
Reviews
Original Publications
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Time of last update: 2024-11-13 09:44:32
Author of last update: Jstuelk