ftsZ
168

cell-division initiation protein (septum formation)

Locus

BSU_15290

Molecular weight

40.20 kDa

Isoelectric point

4.81

Protein length

382 aaSequenceBlast

Gene length

1149 bpSequenceBlast

Function

formation of Z-ring

Product

cell-division initiation protein (septum formation), member of the divisome

Essential

yes

Synonyms

ftsZ, ts-1

Outlinks

BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Hide small RNAsZoom:

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0206 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene

Coordinates

1,597,832 1,598,980

Phenotypes of a mutant

essential PubMed, but dispensible in L-forms PubMed

The protein

Protein family

FtsZ family (single member, according to UniProt)

Structure

2VAM (PDB)

2RHL (PDB) (dimer with GDP)

4U39 (PDB) (FtsZ-MciZ complex) PubMed

P17865 (AlphaFold)

Effectors of protein activity

Z ring formation is inhibited upon binding of MciZ to FtsZ

bundling of FtsZ protofilaments into strikingly long and regular tubular structures reminiscent of eukaryotic microtubules requires the prior formation of large ring polymers of SepF PubMed

interaction with UgtP inhibits FtsZ filament formation PubMed

FtsZ polymerization is inhibited by interaction with MinC PubMed

Z ring formation requires PdhA in a pyruvate-dependent manner PubMed

Localization

during vegetative growth: uniform FtsA-FtsZ rings around the leading edge of the invaginating medial septum to orchestrate cell division (FtsA is proximal to the membrane and tethers FtsZ) PubMed

at the onset of sporulation: FtsA-FtsZ filaments are assembled only on the mother cell side of the invaginating polar septum, this depends on SpoIIE PubMed

Expression and Regulation

Operons

Genes

ftsA-ftsZ

Description

PubMed

Regulation

activated by WalR PubMed

Regulatory mechanism

WalR: activation, in walR regulon

Sigma factors

SigA: sigma factor, PubMed, in sigA regulon

SigH: sigma factor, PubMed, in sigH regulon

Additional information

half-life of the ''ftsZ'' mRNA: 2.2 min PubMed

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Biological materials

Expression vectors

GP2009: expression of ftsZ-Strep under control of the ftsZ promoter (based on pGP1389), available in Jörg Stülke's lab

Two-hybrid system

B. pertussis adenylate cyclase-based bacterial two hybrid system (BACTH), available in Jörg Stülke's lab

Antibody

available in the Jeff Errington lab

Labs working on this gene/protein

Imrich Barak, Slovak Academy of Science, Bratislava, Slovakia homepage

Leendert Hamoen, CBCB, Newcastle University, UK

References

Reviews

Original Publications

FtsZ as antibacterial drug target

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Time of last update: 2025-04-08 00:22:25

Author of last update: Jstuelk

ftsZ 168

ftsZ
168