coaA
168
type I pantothenate kinase, major enzyme
locus
BSU_23760
Molecular weight
36.49 kDa
pI
5.89
function
biosynthesis of coenzyme A
product
pantothenate kinase, pantetheine kinase
essential
no
ec
2.7.1.33
synonyms
coaA, yqjS, panK
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1072 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
2,468,549 → 2,469,508
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The protein
Catalyzed reaction/ biological activity
(R)-pantothenate + ATP --> (R)-4'-phosphopantothenate + ADP + H+ [https://www.biorxiv.org/content/10.1101/2024.04.17.589903v1.full.pdf bioRxiv]
pantetheine + ATP --> phosphopantetheine+ ADP + H+ [https://www.biorxiv.org/content/10.1101/2024.04.17.589903v1.full.pdf bioRxiv]
Protein family
prokaryotic pantothenate kinase family (single member, according to UniProt)
Structure
[PDB|1SQ5] (from ''Escherichia coli'', 49% identity, 67% similarity) [Pubmed|15136582]
[AF|P54556]
Expression and Regulation
Operons
genes
[gene|35B40D812B123766B469B8E5C0FE0EB69F671E4E|yqjP]-[gene|0927C7D45721F47F5ED2646CAAC324A308FD7724|yqjQ]-[gene|4E7390A74A8261E8B732E94859E90FE256AD64EE|dsdA]-[gene|B3362449EF3C9D533090FBD7E7333A3CC5D902CB|coaA]-[gene|441DCE4251C83FCBB01BC58720900365BFE7BB3D|yqjT]
description
[pubmed|22383849]
Biological materials
Mutant
MGNA-C399 (yqjS::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/2397 NBRP B. subtilis, Japan]
BKE23760 (Δ[gene|B3362449EF3C9D533090FBD7E7333A3CC5D902CB|coaA]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE23760 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CACTGTTTACACCTGACTCT, downstream forward: _UP4_GTGTTGGTAAGGAGGGTATG
BKK23760 (Δ[gene|B3362449EF3C9D533090FBD7E7333A3CC5D902CB|coaA]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK23760 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CACTGTTTACACCTGACTCT, downstream forward: _UP4_GTGTTGGTAAGGAGGGTATG
GP3355 (''[gene|B3362449EF3C9D533090FBD7E7333A3CC5D902CB|coaA]''::lox72), available in [wiki|Jörg Stülke]'s lab
GP3380 ([gene|B3362449EF3C9D533090FBD7E7333A3CC5D902CB|coaA]::neo trpC2), available in [wiki|Jörg Stülke]'s lab
References
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Time of last update: 2024-11-28 19:38:36
Author of last update: Jstuelk