coaA

coaA
168

type I pantothenate kinase, major enzyme

Locus
BSU_23760
Molecular weight
36.49 kDa
Isoelectric point
5.89
Protein length
319 aaSequenceBlast
Gene length
960 bpSequenceBlast
Function
biosynthesis of coenzyme A
Product
pantothenate kinase, pantetheine kinase
Essential
no
E.C.
2.7.1.33
Synonyms
coaA, yqjS, panK
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1072 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
2,468,549 → 2,469,508
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The protein
Catalyzed reaction/ biological activity
(R)-pantothenate + ATP --> (R)-4'-phosphopantothenate + ADP + H+ bioRxiv
pantetheine + ATP --> phosphopantetheine+ ADP + H+ bioRxiv
Protein family
prokaryotic pantothenate kinase family (single member, according to UniProt)
Structure
1SQ5 (PDB) (from Escherichia coli, 49% identity, 67% similarity) PubMed
P54556 (AlphaFold)
Expression and Regulation
Operons
Genes
yqjP-yqjQ-dsdA-coaA-yqjT
Description
PubMed
Open in new tab

yqjP→yqjT

2025-04-08 15:13:29

Jstuelk

104

849135de1757b2b3b5c94019b4a82218149cb07b

7866C7C07985979A54369C1D59D36565C48D9B56

Biological materials
Mutant
MGNA-C399 (yqjS::erm), available at the NBRP B. subtilis, Japan
BKE23760 (ΔcoaA::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CACTGTTTACACCTGACTCT,  downstream forward: _UP4_GTGTTGGTAAGGAGGGTATG
BKK23760 (ΔcoaA::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CACTGTTTACACCTGACTCT,  downstream forward: _UP4_GTGTTGGTAAGGAGGGTATG
GP3355 (''coaA''::lox72), available in Jörg Stülke's lab
GP3380 (coaA::neo trpC2), available in Jörg Stülke's lab
References
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B3362449EF3C9D533090FBD7E7333A3CC5D902CB

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Time of last update: 2025-04-07 11:02:19

Author of last update: Jstuelk